281676-92-4Relevant academic research and scientific papers
Asymmetric aldol reaction catalyzed by a chiral phosphine-silver complex
Yanagisawa, Akira,Miyake, Ryoji,Yoshida, Kazuhiro
, p. 4248 - 4253 (2014/07/21)
A catalytic asymmetric aldol reaction of alkenyl trihaloacetates or a γ,δ-unsaturated δ-lactone with aldehydes or an α-keto ester was achieved by using a 2,2′-bis(diphenylphosphino)-1,1′- binaphthyl·silver trifluoromethanesulfonate complex as the chiral p
Asymmetric direct aldol reaction of cyclohexanone catalyzed by (N′-benzyl-N′-D-prolyl)-trans-4-hydroxy-L-proline hydrazide
Cheng, Chuanling,Wang, Wenliang
scheme or table, p. 196 - 198 (2012/03/27)
A new proline catalyst, namely (N′-benzyl-N′-D-prolyl)-trans-4- hydroxy-L-proline hydrazide, has been prepared and proved to be a superior catalyst for the asymmetric aldol reaction of cyclohexanone and aromatic aldehydes, affording up to 98:2 dr and 98%
Organocatalytic direct asymmetric aldol reactions in water
Mase, Nobuyuki,Nakai, Yusuke,Ohara, Naoko,Yoda, Hidemi,Takabe, Kunihiko,Tanaka, Fujie,Barbas III, Carlos F.
, p. 734 - 735 (2007/10/03)
We have developed direct asymmetric cross-aldol reactions that can be performed in water without addition of organic solvents. A bifunctional catalyst with a long hydrophobic alkyl chain efficiently catalyzed the reactions and afforded the desired aldol p
Catalytic asymmetric aldol reaction of trimethoxysilyl enol ethers using 2,2′-bis(di-p-tolylphosphino)-1,1′-binaphthyl·AgF complex
Yanagisawa,Nakatsuka,Asakawa,Wadamoto,Kageyama,Yamamoto
, p. 1477 - 1484 (2007/10/03)
Catalytic asymmetric Mukaiyama-type aldol reaction using trimethoxysilyl enol ethers was achieved using 2,2′-bis(di-p-tolylphosphino)-1,1′-binaphthyl (p-Tol-BINAP)·AgF complex as a catalyst. The chiral silver(I) catalyst was easily generated by mixing p-Tol-BINAP and silver(I) fluoride in MeOH at room temperature. High syn- and enantioselectivities were obtained from both the E- and Z-silyl enol ethers. Use of a 1:1 mixture of MeOH and acetone as a solvent in the reaction of cyclohexanone-derived trimethoxysilyl enol ethers resulted in higher enantioselectivity.
