28170-90-3Relevant academic research and scientific papers
Multi-stimuli controlled release of a transmembrane chloride ion carrier from a sulfonium-linked procarrier
Akhtar, Nasim,Biswas, Oindrila,Das, Sribash,Manna, Debasis,Patel, Anjali
, p. 9246 - 9252 (2020)
In recent times, anion transporters have received substantial consideration due to their ability to disrupt the ionic equilibrium across membrane bilayers. While numerous Cl- ion transporters were developed for channelopathies, unfortunately, poor aqueous solubility precluded their bioapplicability. Herein, we demonstrate the development of a multi-stimuli activatable anion transport approach to induce regulated transport of Cl- ions across membranes under specific conditions. The sulfonium-based procarrier was initially inactive, but the transmembrane transport of Cl- ions was activated in the presence of stimuli such as glutathione (GSH), reactive oxygen species (ROS) and light. The release of the hydrophobic anionophore from the aqueous-soluble procarrier under specific conditions leads to the successful transport of Cl- ions. Under physiological conditions, these anion carriers follow an antiport exchange mechanism to transport Cl- ions across lipid bilayers. Such multi-stimuli activatable procarriers have great potential to combat various types of channelopathies, including cancer, cystic fibrosis, kidney stones, myotonia, and others.
NSCLC structure-activity relationship (sar) study of diisothiocyanates for antiproliferative activity on A549 Human non-small cell lung carcinoma (NSCLC)
Chatwichien, Jaruwan,Prachavna, Buntarika,Suntivich, Rinrada,Kumphune, Sarawut
, p. 569 - 574 (2019/08/07)
Isothiocyanate functional group (-N=C=S) is widely accepted as an important moiety for anti-cancer effects of naturally occurring isothiocyanate compounds (ITCs). Herein, a series of diisothiocyanate (diITCs) derivatives were synthesized and evaluated in antiproliferative assays on A549 human non-small cell lung cancer and IMR90 human foetal lung cell lines for structure-activity relationship (SAR) and cancer cell selectivity studies. Results showed that aliphatic and benzylic diITCs were more cytotoxic to A549 cells than natural ITCs; benzyl isothiocyanate (BITC) and phenyl isothiocyanate (PITC), and a currently available anticancer drug; etoposide. Aromatic diITCs were not as active. Notably, most of the diITCs reported in this work were significantly more selective than etoposide to inhibit proliferation of the cancer cells (A549) over the normal cells (IMR90). This study demonstrated a guideline to modify chemical structures of diITCs for anti-NSCLC agents.
A sulfur key Lian Niao multifunctional synergistic antioxidant stabilizer preparation method
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Paragraph 0033; 0034; 0035; 0036; 0037, (2017/05/12)
The invention relates to a preparation method of a multi-functional synergetic anti-oxidative stabilizer for sulfide bond linked urea. The preparation method comprises the following steps: (1) adding organic amine into CS2 and alkali to react; adding meth
A thiourea multifunctional synergistic antioxidant stabilizer and its preparation method and application
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Paragraph 0044-0048, (2017/01/31)
The invention relates to a multi-functional synergetic anti-oxidative stabilizer for thiourea as well as a preparation method and application thereof. The multi-functional synergetic anti-oxidative stabilizer has a structure shown in the specification, wh
Synthesis and biological activity of novel symmetrical bis-2- phenyliminothiazolidine derivatives
Li, Gang-Yue,Qian, Xu-Hong,Yan, Sheng-Gang,Cui, Jing-Nan,Huang, Qing-Chun,Zhang, Rong,Liu, Feng-Yu,Cui, Da-Wei
, p. 2851 - 2861 (2007/10/03)
A series of novel symmetrical bis-2-phenyliminothiazolidine derivatives were designed and synthesized. The structures of all the title compounds were characterized by 1H NMR and, in some cases, by 13C NMR, IR, and high-resolution mas
Novel self-assembly of m-xylylene type dithioureas by head-to-tail hydrogen bonding
Tobe, Yoshito,Sasaki, Shin-Ichi,Mizuno, Masaaki,Hirose, Keiji,Naemura, Koichiro
, p. 7481 - 7489 (2007/10/03)
Dithiourea la self-assembles to form an orthogonal dimer structure both in solution and in the solid state, wherein the four thiourea groups establish a closed network of hydrogen bonds through a head-to-tail binding mode. This novel dimer structure was elucidated on the basis of 1H NMR spectra, vapor pressure osmometry, and X-ray crystal structure analysis. Furthermore, a series of m-xylylene type dithioureas were synthesized and their dimerization constants (Ka) in CDCl3 were determined by dilution experiments using 1H NMR spectroscopy. The magnitude of the Ka values are dependent on the steric bulk of the side chains, the acidity of the thiourea groups, and the weak intermolecular interaction between the benzene rings of the side chains and the m-xylylene spacer.
Acceleration of Substitution Reactions of a Phosphoric Acid Diester by Bis(guanidinium) Compounds
Gross, Ralf,Duerner, Gerd,Goebel, Michael W.
, p. 49 - 58 (2007/10/02)
Ion-pair coordination of phosphoric acid diesters with positively charged guanidines may cause large rate accelerations in substitution reactions.Here we present a comparative study on the catalytical influence of several mono- bis- and tris(guanidines) a
VINYL ETHERS CONTAINING AN EPOXY GROUP. XV. REACTION WITH A PRIMARY AMINECARBON BISULFIDE SYSTEM
Nedolya, N. A.,Komel'kova, V. I.,Trofimov, B. A.
, p. 250 - 254 (2007/10/02)
The S--2-hydroxypropyl> esters of the corresponding N-monosubstituted dithiocarbamic acids, which are new representatives of functionally substituted vinyl ethers, were obtained by the reaction of glycidol vinyloxyethyl ether with a primary amine-carbon bisulfide system.
