282090-94-2Relevant academic research and scientific papers
2-Aryl-2,2-difluoroacetamide FKBP12 Ligands: Synthesis and X-ray Structural Studies
Dubowchik, Gene M.,Vrudhula, Vivekananda M.,Dasgupta, Bireshwar,Ditta, Jonathan,Chen, Ti,Sheriff, Steven,Sipman, Karin,Witmer, Mark,Tredup, Jeffrey,Vyas, Dolatrai M.,Verdoorn, Todd A.,Bollini, Sagarika,Vinitsky, Alexander
, p. 3987 - 3990 (2001)
2-Aryl-2,2-difluoroacetamido-proline and pipecolate esters are high affinity FKBP12 ligands whose rotamase inhibitory activity is comparable to that seen for the corresponding ketoamides. X-ray structural studies suggest that the fluorine atoms participat
