282094-26-2Relevant articles and documents
Design of a new bifunctional asymmetric catalyst from carbohydrates: Application to catalytic asymmetric cyanosilylation of aldehydes and acetophenone
Kanai, Motomu,Hamashima, Yoshitaka,Shibasaki, Masakatsu
, p. 2405 - 2409 (2000)
A new active Lewis acid-Lewis base bifunctional asymmetric catalyst 7 was developed using carbohydrate as a scaffold and this catalyst was applied to the asymmetric cyanosilylation of aldehydes and acetophenone. The β-Ph group at the 6-position of 7 was found to be important for a high asymmetric induction (up to 80% ee) by bringing the Al and the phosphine oxide at optimum positions for a dual activation of carbonyl compounds and TMSCN. (C) 2000 Elsevier Science Ltd.