28269-02-5Relevant articles and documents
PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS
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Page/Page column 299-300; 360-362, (2020/10/18)
This disclosure provides pharmaceutical compounds to treat medical disorders, such as complement-mediated disorders, including complement Cl -mediated disorders.
Enantioselective synthesis of an advanced intermediate for the synthesis of brefeldin A and analogues
Legrand, Frédéric,Archambaud, Sylvie,Collet, Sylvain,Aphecetche-Julienne, Karine,Guingant, André,Evain, Michel
, p. 389 - 393 (2008/09/17)
A synthesis of methyl (1R,2R,4S)-2-[(E)-2-iodovinyl]-4-(methoxymethoxy) cyclopentanecarboxylate is described in nine steps from a prochiral anhydride. A desymmetrization reaction followed by an epimerization and a Takai reaction are the key steps of the t
Toward the total synthesis of variecolin
Molander, Gary A.,Quirmbach, Michael S.,Silva Jr., Luiz F.,Spencer, Keith C.,Balsells, Jaume
, p. 2257 - 2260 (2007/10/03)
(matrix presented) An annulative approach toward the total synthesis of the sesterterpenoid variecolin (1) is presented. Synthesis of the key hemiketal, containing the core ABC ring skeleton, has been achieved on a model system by an expeditious route uti