28277-71-6

Upstream product

• 186581-53-3 diazomethane 
• 49715-41-5 1-hydroxy-2,10-dimethoxyaporphine 
• 79076-29-2 1-hydroxy-2,10-dimethoxy-9-phenoxyaporphine 

Downstream Products

• 82444-06-2 1,2,10-trimethoxy-6-methyl-6aα-aporphane 
• 28277-71-6 3,5,6-Trimethoxy-aporphin 

Relevant academic research and scientific papers

STUDIES ON TETRAHYDROISOQUINOLINES. XIX. SYNTHESIS OF (+/-)-ISOTHEBAINE, (+/-)-1-HYDROXY-2,9-DIMETHOXY-, (+/-)-1-HYDROXY-2,10-DIMETHOXY-, AND (+/-)-2,10-DIMETHOXY-APORPHINES,(+/-)-2,6-DIMETHOXYHOMOMORPHINANDIENONE, AND (+/-)-1-HYDROXY-2,10-DIMETHOXYHOMOAP

The title alkaloids and two related aporphines have been prepared in considerable yields by trifluoroacetic acid treatment of the corresponding p-quinol acetates.Keywords: oxidation; lead tetraacetate; p-quinol acetate; lirinine; trifluoroacetic acid; cyc

Synthesis of hernandaline

There is disclosed a novel and improved method of synthesizing aporphines utilizing the Pschorr cyclization of 1-(2'-aminobenzyl)-7 hydroxy-1,2,3,4-tetrahydroisoquinolines in place of the corresponding 7-methoxy compounds. In the novel process of the present invention the amino group is diazotized and cyclized in the presence of copper powder.