28286-05-7

Upstream product

• 34737-83-2 1-methylpiperidin-4-one hydrochloride 
• 107-21-1 ethylene glycol 
• 1445-73-4 1-Methyl-4-piperidone 
• 73390-09-7 4,4-Dihydroxy-1-methylpiperidinium-chlorid 

Downstream Products

• 51787-77-0 1,4-dioxa-8-aza-spiro[4.5]decane-8-carboxylic acid ethyl ester 
• 73390-10-0 1-methylpiperidine-4-spiro-2'-dioxolane methiodide 
• 35488-00-7 1-methyl-2,3-dihydro-4-pyridone 
• 51787-84-9 4-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)-4'-fluorobutyrophenone 
• 51787-82-7 8-[4,4-bis-(4-fluoro-phenyl)-butyl]-1,4-dioxa-8-aza-spiro[4.5]decane 
• 177-11-7 4,4-ethylenedioxy-piperidine 

Relevant academic research and scientific papers

1,3-Dioxolanes of N-Substituted 4-Piperidones as Substrates for Dehydrogenations

The applicability of ketals was examined for masking the carbonyl group in N-tertiary 4-piperidones during the dehydrogenation using mercury-edta. Various 1,3-dioxolanes showed a different behaviour in dependence on the N-substituent. With simple aliphatic moieties mainly dehydrogenated but hydrolyzed products were received. These enaminones were also available from the dehydrogenations of the corresponding 4-piperidones. Similar applied to para-acyl-aromatic substituted derivatives but with less yields. Aromatic substituents bearing a neighbour group on ortho-position with participation gave rise to different oxidation products partially with preservation of the ketal structure.