51787-77-0

Basic information

• Product Name: ethyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate
• Synonyms: ethyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate;1,4-Dioxa-8-azaspiro[4.5]decane-8-carboxylic acid ethyl ester;Einecs 257-418-3
• CAS NO: 51787-77-0
• Molecular Formula: C₁₀H₁₇NO₄
• Molecular Weight: 215.24628
• EINECS: 257-418-3
• Mol File: 51787-77-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 314.8°C at 760 mmHg
• Flash Point: 144.2°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 0.000456mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: ethyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate(51787-77-0)
• EPA Substance Registry System: ethyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate(51787-77-0)

Safety Data

• Hazardous Substances Data: 51787-77-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H17NO4/c1-2-13-9(12)11-5-3-10(4-6-11)14-7-8-15-10/h2-8H2,1H3

Upstream product

• 28286-05-7 8-Methyl-1,4-dioxa-8-azoniaspiro<4.5>decan 
• 541-41-3 chloroformic acid ethyl ester 
• 37943-54-7 8-benzyl-1,4-dioxa-8-azaspiro[4.5]decane 
• 34737-83-2 1-methylpiperidin-4-one hydrochloride 
• 20821-52-7 1-benzyl-4-piperidone hydrochloride 
• 177-11-7 4,4-ethylenedioxy-piperidine 

Downstream Products

• 29976-53-2 N-ethoxycarbonyl-4-piperidone 
• 177-11-7 4,4-ethylenedioxy-piperidine 

Relevant articles and documents

Synthesis of bicyclic aza-enones via a lewis acid catalysed Michael-type addition with silyl enol ethers bearing a nitrogen atom

Silyl enol ethers bearing a nitrogen atom protected by an electron-withdrawing group give in high yield a Micheal-type addition with hemiacetal vinylog or a mixture of methyl vinyl ketone and an alcohol in the presence of boron trifluoride etherate as a catalyst. The aza-1,5-diketones so prepared can be cyclised leading to aza-enones precursors of some biologycally active structures.