2829-26-7

Basic information

• Product Name: 1-(4-Chlorobenzylidene)-2-phenylhydrazine
• Synonyms: 1-(4-Chlorobenzylidene)-2-(phenyl)hydrazine;1-(4-Chlorobenzylidene)-2-phenylhydrazine;4-Chlorobenzaldehyde phenylhydrazone;N-Phenyl-4-chlorobenzaldehyde hydrazone;p-Chlorobenzaldehyde phenyl hydrazone;N-[(4-chlorophenyl)methylideneamino]aniline
• CAS NO: 2829-26-7
• Molecular Formula: C₁₃H₁₁ClN₂
• Molecular Weight: 230.69
• Mol File: 2829-26-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 353.4°C at 760 mmHg
• Flash Point: 167.6°C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 3.58E-05mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 1-(4-Chlorobenzylidene)-2-phenylhydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Chlorobenzylidene)-2-phenylhydrazine(2829-26-7)
• EPA Substance Registry System: 1-(4-Chlorobenzylidene)-2-phenylhydrazine(2829-26-7)

Safety Data

• Hazardous Substances Data: 2829-26-7(Hazardous Substances Data)

Usage

General Description

1-(4-Chlorobenzylidene)-2-phenylhydrazine is a chemical compound with the molecular formula C14H13ClN2. It is a hydrazine derivative that contains a chlorobenzylidene group and a phenyl group. 1-(4-Chlorobenzylidene)-2-phenylhydrazine is often used as a building block in the synthesis of various organic compounds, especially in the pharmaceutical industry. Its unique structure and reactivity make it a valuable intermediate for the production of potential drugs and bioactive molecules. However, it is important to handle this chemical with care, as it may pose risks to human health and the environment if not managed properly.

InChI:InChI=1/C13H11ClN2/c14-12-8-6-11(7-9-12)10-15-16-13-4-2-1-3-5-13/h1-10,16H

Upstream product

• 873-76-7 para-Chlorobenzyl alcohol 
• 62-53-3 aniline 
• 59-88-1 phenylhydrazine hydrochloride 
• 104-88-1 4-chlorobenzaldehyde 
• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 100-63-0 phenylhydrazine 
• 3848-36-0 4-chlorobenzaldoxime 
• 89809-77-8 ethyl 6-amino-4-(4-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate 

Downstream Products

• 1622-15-7 3-(4-chlorophenyl)-1,5-diphenylformazan 
• 39677-85-5 4-chloro-N'-(2,4-dibromo-phenyl)-benzohydrazonoyl bromide 
• 466674-08-8 [3-(4-chloro-phenyl)-1,5-diphenyl-4,5-dihydro-1H-pyrazol-4-yl]-[3-(4-chloro-phenyl)-4-methyl-1,5-diphenyl-4,5-dihydro-1H-pyrazol-4-yl]-methanone 
• 466674-11-3 [3-(4-chloro-phenyl)-5-(4-methoxy-phenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl]-[3-(4-chloro-phenyl)-4-methyl-1,5-diphenyl-4,5-dihydro-1H-pyrazol-4-yl]-methanone 
• 466674-30-6 [3-(4-chloro-phenyl)-5-(4-methoxy-phenyl)-4,5-dihydro-isoxazol-4-yl]-[3-(4-chloro-phenyl)-4-methyl-1,5-diphenyl-4,5-dihydro-1H-pyrazol-4-yl]-methanone 
• 1146959-99-0 6-[2-(4-chlorobenzylidene)-1-phenylhydrazinyl]-3-methyl-5-nitropyrimidine-2,4(1H,3H)-dione 
• 23982-86-7 1-benzyl-2-(4-chlorophenyl)-1H-benzo[d]imidazole 
• 1608493-90-8 4-chloro-3-(4-chlorophenyl)-1,5-diphenyl-1H-pyrazole 
• 1608493-88-4 3-(4-chlorophenyl)-4-nitro-1,5-diphenyl-1H-pyrazole 
• 1608493-89-5 4-bromo-3-(4-chlorophenyl)-1,5-diphenyl-1H-pyrazole 

Relevant articles and documents

Broad-Spectrum Antifungal Agents: Fluorinated Aryl- and Heteroaryl-Substituted Hydrazones

Fluorinated aryl- and heteroaryl-substituted monohydrazones displayed excellent broad-spectrum activity against various fungal strains, including a panel of clinically relevant Candida auris strains relative to a control antifungal agent, voriconazole (VRC). These monohydrazones displayed less hemolysis of murine red blood cells than that of VRC at the same concentrations, possessed fungicidal activity in a time-kill study, and exhibited no mammalian cell cytotoxicity. In addition, these monohydrazones prevented the formation of biofilms that otherwise block antibiotic effectiveness and did not trigger the development of resistance when exposed to C. auris AR Bank # 0390 over 15 passages.

Facile One-Pot Transformation of Primary Alcohols into 3-Aryl- and 3-Alkyl-isoxazoles and -pyrazoles

Various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylisoxazoles in good yields in one pot by successive treatment with PhI(OAc) 2 in the presence of TEMPO, NH 2 OH, and then NCS, followed by reaction with alkynes in the presence of Et 3 N. Similarly, various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylpyrazoles in good yields in one pot by successive treatment with PhI(OAc) 2 in the presence of TEMPO, PhNHNH 2, and then NCS and decyl methyl sulfide, followed by reaction with alkynes in the presence of Et 3 N. Thus, both 3-aryl- and 3-alkylisoxazoles, and 3-aryl- and 3-alkylpyrazoles could be prepared from readily available primary alcohols in one pot under transition-metal-free conditions.

Mild and efficient conversion of oximes into arylhydrazones catalysed by ferric perchlorate

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