89809-77-8

Upstream product

• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 141-97-9 ethyl acetoacetate 
• 19411-80-4 (Z)-ethyl 2-(4-chlorobenzylidene)-3-oxobutanoate 
• 109-77-3 malononitrile 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 119337-21-2 ethyl 4,7-bis(4-chlorophenyl)-8,8-dicyano-2-methyl-5-oxo-1,6-diazanaphthalene-3-carboxylate 
• 89607-39-6 6‐amino‐3‐methyl‐ 4‐(4‐chlorophenyl)‐1,4‐dihydropyrano[2,3‐c]pyrazole‐5‐carbonitrile 
• 169267-84-9 ethyl 4-chloro-5-(4-chlorophenyl)-2-dimethylamino-7-methyl-5H-pyrano<2,3-d>pyrimidin-6-carboxylate 
• 94640-17-2 4-(4-chloro-phenyl)-5-cyano-2-methyl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Study of supramolecular self-assembly of pyridone and dihydropyridone co-crystal: Synthesis, crystal structure, Hirshfeld surface, DFT and molecular docking studies

Dihydropyridone is synthesized by the multicomponent condensation reactions (MCRs), followed by three different oxidation methods to synthesize pyridone. The 3-D self-assemblies of both the compounds were determined using the single-crystal X-ray diffraction method. Dihydropyridone products are found as a racemic mixture in synthesis and crystalized as co-crystal. Similar structural conformations are observed in both the compounds but stabilized with different non-covalent interactions. Hirshfeld surface analysis is done to analyze the various intermolecular interactions in both the structure. This study gives the clue of driving force in the self-assembly of molecules in crystal lattices. The propensity of inter-molecular contacts to construct the supramolecular assembly was further studied using DFT. The geometrical optimizations of both the compounds were done by the electronic structure method using density functional theory (DFT) to identify the active sites and explore the molecules' chemically reactive parameters. Further, both compounds were docked with Survivin Protein and Kinesin Eg5 protein to analyze the binding affinity with targeted protein.

Mesoporous KIT-6 supported ionic liquids as new and highly effective heterogeneous catalysts for three-component synthesis of 2-amino-3-cyano-4H-pyrans

A series of mesoporous KIT-6 supported ionic liquids were prepared and tested as effective and practical catalysts for the synthesis of 2-amino-3-cyano-4H-pyrans. The effects of type of catalysts, catalyst amount, and catalyst stability have also been inv

Novel pyrano-triazolo-pyrimidine derivatives as anti- α-amylase agents: Synthesis, molecular docking investigations and computational analysis

A novel series of pyranotriazolopyrimidine derivatives 3a-j was synthesized and characterized by 1H NMR, 13C NMR, and HRMS experimental data. The synthesized compounds were assessed for their inhibitory potential on the α-amylase enz

Functionalization of Ethyl 6-Amino-4-(4-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate: Facile Synthesis of a New Series of Pyrano[2,3-d]pyrimidine Derivatives

Abstract: Herein, synthesis of a new series of pyrano[2,3-d]pyrimidine scaffolds is presented. Ethyl 6-amino-4-(4-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate has been reacted with formamide, formic acid, urea, thiourea, semicarbazide, and thiose

Ferric Sulfasalazine Sulfa Drug Complex Supported on Cobalt Ferrite Cellulose; Evaluation of Its Activity in MCRs

Abstract: The green and nano catalyst was simply prepared through the reaction of ferric sulfasalazine with nanomaterial CoFe2O4-cellulose as a magnetic biopolymer surface. This novel heterogeneous organometallic catalyst was charact

Preparation and characterization of Ca-modified Co/Al2O3 and its catalytic application in the one-pot synthesis of 4H-pyrans

Abstract: In this research, Co/Ca–Al2O3 composite as a heterogeneous nanocatalyst was synthesized by the co-precipitation method. The effect of Ca addition on the textural properties and the catalytic activity was investigated. The r

A Novel Biopolymer-based Nanomagnetic Catalyst for the Synthesis of 4H-pyran and Tetrahydro-4H-chromene Derivatives

In the present study, we have designed and synthesized a new magnetically recoverable, nanocatalyst of Ag/Fe3O4?starch. The successful synthesis and the structure of the nanocatalyst were confirmed and evaluated with several analytical techniques including XRD, EDX, VSM, FT-IR, TEM and TGA. The impact and efficiency of Ag/Fe3O4?starch were successfully investigated in the one-pot synthesis of desired 4H-pyrans and tetrahydro-4H-chromenes using three-component condensation of various aldehydes, malononitrile, and 1,3-diketoesters or cyclic 1,3-diketones. The magnetic nanocatalyst was easily recovered and reused with high catalytic activity even after up to five runs.

Novel biocompatible core/shell Fe3O4?NFC?Co(ii) as a new catalyst in a multicomponent reaction: An efficient and sustainable methodology and novel reusable material for one-pot synthesis of 4: H -pyran and pyranopyrazole in aqueous media

Today, due to the developing need for inexpensive catalysts, recyclable magnetic nanocatalysts immobilized on polysaccharides possess many advantages over classical heterogeneous catalysts. However, cellulose has been an appealing material in catalysis sc

Biocatalytic tandem multicomponent reactions for one-pot synthesis of 2-Amino-4H-Pyran library and in vitro biological evaluation

A simple, effective and ecofriendly biocatalytic method has been developed to construct 2-amino-4H-pyrans via tandem multi-component reaction (MCR) of aldehyde, malononitrile and ethyl acetoacetate in one pot. The catalytic activity of lipases in differen

Synthesis of novel multi-OH functionalized ionic liquid and its application as dual catalyst-solvent for the one-pot synthesis 4H-pyrans

In the present work, triethanolammonium 3-hydroxypropane-1-sulfonate [TEA][HPS] as a novel multi-OH functionalized ionic liquid was synthesized. [TEA][HPS] was characterized by 1HNMR, 13CNMR, FT-IR and elemental analysis. In addition