2830-42-4

Upstream product

• 4427-92-3 4-Phenyl-1,3-dioxolan-2-one 
• 70-11-1 α-bromoacetophenone 
• 100-46-9 benzylamine 
• 14562-29-9 carbamic acid-(2-hydroxy-1-phenyl-ethyl ester) 
• 94-35-9 styramate 
• 75-44-5 phosgene 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 3173-56-6 benzyl isothiocyanate 

Downstream Products

• 100-46-9 benzylamine 
• 42116-44-9 N-tert-butoxycarbonylbenzylamine 
• 6648-22-2 3-benzyl-5-bromo-4-phenyl-3H-oxazol-2-one 
• 6648-24-4 3-benzyl-4-phenyl-3H-oxazol-2-one 
• 6648-14-2 3-benzyl-4-hydroxy-4-phenyl-oxazolidin-2-one 

Relevant academic research and scientific papers

Unlocking the potential of phenacyl protecting groups: CO2-based formation and photocatalytic release of caged amines

Orthogonal protection and deprotection of amines remain important tools in synthetic design as well as in chemical biology and material research applications. A robust, highly efficient, and sustainable method for the formation of phenacyl-based carbamate esters was developed using CO2 for the in situ preparation of the intermediate carbamates. Our mild and broadly applicable protocol allows for the formation of phenacyl urethanes of anilines, primary amines, including amino acids, and secondary amines in high to excellent yields. Moreover, we demonstrate the utility by a mild and convenient photocatalytic deprotection protocol using visible light. A key feature of the [Ru(bpy)3](PF6)2-catalyzed method is the use of ascorbic acid as reductive quencher in a neutral, buffered, two-phase acetonitrile/water mixture, granting fast and highly selective deprotection for all presented examples.

Elevation of HDL cholesterol by 2-[(aminothioxomethyl)-hydrazono]-2-arylethyl carbamates

This invention relates to the treatment of atherosclerosis via raising the level of HDL cholesterol by administration of a compound of the formula STR1 wherein: R1, R2, and R3 are independently hydrogen, C1 -C6 alkyl or --(CH2)0-6 Ph where Ph is phenyl optionally substituted by halogen, cyano, nitro, C1 -C6 alkyl, C1 -C6 alkoxy, trifluoromethyl, C1 -C6 alkoxycarbonyl, --CO2 H or OH; R4 and R5 are independently hydrogen, C1 -C6 alkyl, C3 -C8 cycloalkyl, or --(CH2)0-6 Ar1 where Ar1 is phenyl, naphthyl, furanyl, pyridinyl or thienyl and Ar1 can be optionally substituted by halogen, cyano, nitro, C1 -C6 alkyl, phenyl, C1 -C6 alkoxy, phenoxy, trifluoromethyl, C1 -C6 alkoxycarbonyl, --CO2 H or OH; and Ar is phenyl, naphthyl, furanyl, pyridinyl or thienyl or Ar is optionally substituted by halogen, cyano, nitro, C1 -C6 alkyl, C3 -C6 cycloalkyl, phenyl, C1 -C6 alkoxy, phenoxy, trifluoromethyl, C1 -C6 alkoxycarbonyl, --CO2 H or OH.