93415-79-3

Usage

Uses

Used in Organic Synthesis:
METHYL 2-IODO-3-NITROBENZOATE is used as a reagent for the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structure and reactivity contribute to the synthesis of a wide range of compounds, enhancing the development of new and improved products in these industries.
Used in Dye and Pigment Production:
In the dye and pigment industry, METHYL 2-IODO-3-NITROBENZOATE serves as an intermediate, playing a crucial role in the production process. Its chemical properties allow for the creation of dyes and pigments with specific characteristics, meeting the demands of various applications.
Used in Research:
METHYL 2-IODO-3-NITROBENZOATE is also utilized by researchers in the field of organic chemistry for studying reaction mechanisms and exploring new synthetic pathways. Its high reactivity provides opportunities for innovative approaches and discoveries in chemical research.

InChI:InChI=1/C8H6INO4/c1-14-8(11)5-3-2-4-6(7(5)9)10(12)13/h2-4H,1H3

Upstream product

• 5398-69-6 2-iodo-3-nitrobenzoic acid 
• 67-56-1 methanol 
• 88-67-5 2-Iodobenzoic acid 
• 95067-27-9 2-acetylamino-3-nitro-benzoic acid methyl ester 
• 134-20-3 2-carbomethoxyaniline 
• 7647-01-0 hydrogenchloride 
• 856789-07-6 bis-(2-methoxycarbonyl-6-nitro-phenyl)-mercury 
• 603-11-2 3-nitrophthalic acid 

Downstream Products

• 93415-85-1 N-(2'-Carbomethoxy-6'-nitrophenyl)-5-amino-4-carbomethoxy-6-nitro-1,3-benzdioxol 
• 894854-30-9 methyl 3-nitro-2-(2-trimethylsilylethynyl)benzoate 
• 618-95-1 methyl 3-nitrobenzoate 
• 1356483-86-7 N-methyl-2-(methyl-amino)-3-nitrobenzamide 
• 1356483-87-8 3-amino-N-methyl-2-(methyl-amino)benzamide 
• 1597416-63-1 (S)-2,2'-(ethyne-1,2-diyl)bis(3-((S)-2-acetamidopropanamido)-N-((S)-1-(isobutylamino)-1-oxopropan-2-yl)benzamide) 
• 1597416-62-0 tert-butyl ((S)-1-((2-iodo-3-(((S)-1-(isobutylamino)-1-oxopropan-2-yl)carbamoyl)phenyl)amino)-1-oxopropan-2-yl)carbamate 
• 1597416-61-9 di-tert-butyl ((2S,2'S)-(((S)-ethyne-1,2-diylbis(3-(((S)-1-(isobutylamino)-1-oxopropan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))bis(1-oxopropane-2,1-diyl))dicarbamate 
• 1597416-60-8 (S)-dimethyl 2,2'-(ethyne-1,2-diyl)bis(3-((S)-2-((tert-butoxycarbonyl)amino)propanamido)benzoate) 
• 1597416-59-5 (S)-methyl 3-(2-((tert-butoxycarbonyl)amino)propanamido)-2-ethynylbenzoate 
• 1613384-13-6 C₃₂H₃₈N₄O₁₀ 
• 1597416-58-4 (S)-methyl 3-(2-((tert-butoxycarbonyl)amino)propanamido)-2-((trimethylsilyl)ethynyl)benzoate 
• 1597416-57-3 (S)-methyl 3-(2-((tert-butoxycarbonyl)amino)propanamido)-2-iodobenzoate 
• 283173-76-2 methyl 3-amino-2-iodobenzoate 

Relevant academic research and scientific papers

A photoredox-neutral Smiles rearrangement of 2-aryloxybenzoic acids

We report on the use of visible light photoredox catalysis for the radical Smiles rearrangement of 2-aryloxybenzoic acids to obtain aryl salicylates. The method is free of noble metals and operationally simple and the reaction can be run under mild batch or flow conditions. Being a redox neutral process, no stoichiometric oxidants or reductants are needed.

BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF

The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s); R2 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); Xa and Xb are each C, N, O or S; Xc and Xd are each C or N; m is 0-2; n is 1-3; ring A is a 5-membered ring optionally having substituent(s); ring B is a 6-membered ring optionally having substituent(s); and ring C is a 3- to 5-membered ring optionally having substituent(s), provided that when Xa, Xc and Xd are each C, then Xb is N or S, or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.

5-Nitroisocoumarins from tandem Castro-Stephens coupling-6-endo-dig cyclisation of 2-iodo-3-nitrobenzoic acid and arylethynes and ring-closure of methyl 2-alkynyl-3-nitrobenzoates with electrophiles

Reaction of 2-iodo-3-nitrobenzoic acid with arylalkynyl copper(I) reagent gave 3-aryl-5-nitroisocoumarins. Castro-Stephens coupling was followed by in situ Cu-catalysed ring-closure. 1H NMR and X-ray crystallography showed the cyclisations to be 6-endo, contrasting with reports of 5-exo cyclisation of analogous 2-iodobenzoate esters with alkynes. Sonogashira couplings of methyl 2-iodo-3-nitrobenzoate with phenylacetylene and with trimethylsilylacetylene gave the corresponding 2-alkynyl-3-nitrobenzoate esters. With HgSO4, the phenylalkyne underwent 6-endo cyclisation to give 5-nitro-3-phenylisocoumarin. The disubstituted alkyne esters gave 4-phenylselenylisocoumarins with PhSeCl. 5-Nitro-3-phenyl-4-phenylselenylisocoumarin shows significant sterically-driven distortion of the isocoumarin ring. Reaction of methyl 3-nitro-2-phenylethynylbenzoate with ICl gave the 4-iodoisocoumarin. Thus the nitro group tends to direct these electrophile-driven cyclisations towards the 6-endo mode.

Tricyclic inhibitors of poly(ADP-ribose) polymerases

Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapuetics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and nuerodegenerative disease. STR1As cancer therapuetics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.

A new synthesis of 'push-pull' naphthalenes by condensation of nitro-2-methylbenzoate esters with dimethylacetamide dimethyl acetal

Whereas condensation of 2-methyl-3-nitrobenzoate esters with dimethylformamide dimethyl acetal gives 5-nitroisocoumarin, analogous condensation with dimethylacetamide dimethyl acetal proceeds via a different route, affording 1-methoxy-3-dimethylamino-5-ni

Synthesis and Chiroptical Properties of Bridged 2,2'-Diaminobiphenyl Derivatives

The relationship between c.d. spectra and the conformation of chiral 2,2'-diaminobiphenyls was investigated as a function of the torsion angle between the benzene ring planes.The molecular structures of (S)-(+)-4,5,6,7,11,12,13,14-octahydrobenzazocino