28330-02-1

Basic information

• Product Name: D-Palmitoylcarnitine chloride
• Synonyms: D-Palmitoylcarnitine chloride
• CAS NO: 28330-02-1
• Molecular Formula: C23H46 N O4 . Cl
• Molecular Weight: 436.07
• Mol File: 28330-02-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: D-Palmitoylcarnitine chloride(CAS DataBase Reference)
• NIST Chemistry Reference: D-Palmitoylcarnitine chloride(28330-02-1)
• EPA Substance Registry System: D-Palmitoylcarnitine chloride(28330-02-1)

Safety Data

• Hazardous Substances Data: 28330-02-1(Hazardous Substances Data)

Upstream product

• 461-06-3 CARNITINE 
• 112-67-4 n-hexadecanoyl chloride 
• 406-76-8 (S)-carnitin 
• 541-15-1 L-carnitine 
• 6645-46-1 L-carnitine chloride 

Downstream Products

• 1935-18-8 L-Palmitoylcarnitine 

Relevant articles and documents

Long-chain acylcarnitines decrease the phosphorylation of the insulin receptor at tyr1151 through a ptp1b-dependent mechanism

The accumulation of lipid intermediates may interfere with energy metabolism pathways and regulate cellular energy supplies. As increased levels of long-chain acylcarnitines have been linked to insulin resistance, we investigated the effects of long-chain acylcarnitines on key components of the insulin signalling pathway. We discovered that palmitoylcarnitine induces dephosphorylation of the insulin receptor (InsR) through increased activity of protein tyrosine phosphatase 1B (PTP1B). Palmitoylcarnitine suppresses protein kinase B (Akt) phosphorylation at Ser473, and this effect is not alleviated by the inhibition of PTP1B by the insulin sensitizer bis-(maltolato)-oxovanadium (IV). This result indicates that palmitoylcarnitine affects Akt activity independently of the InsR phosphorylation level. Inhibition of protein kinase C and protein phosphatase 2A does not affect the palmitoylcarnitine-mediated inhibition of Akt Ser473 phosphorylation. Additionally, palmitoylcarnitine markedly stimulates insulin release by suppressing Akt Ser473 phosphorylation in insulin-secreting RIN5F cells. In conclusion, long-chain acylcarnitines activate PTP1B and decrease InsR Tyr1151 phosphorylation and Akt Ser473 phosphorylation, thus limiting the cellular response to insulin stimulation.

Process for the production of a fatty acid/carnitine derivative

The present invention discloses a process for the production of a fatty acid/L-carnitine.HCl derivative, whereby the educts are reacted in the presence of mono-chloroacetic acid.

On the preparation of O-acyl-derivatives of carnitine

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