28334-99-8Relevant academic research and scientific papers
BROMODOMAIN INHIBITORS FOR TREATING DISEASE
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Paragraph 0200-0201, (2016/03/19)
Disclosed herein are compounds and compositions useful in the treatment of bromodomain-containing protein-mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibiting activity of a bromodomain-containing protein in a human or animal subject are also provided.
SYNTHESIS OF PHLOROGLUCINOL TRIALKYL ETHERS
Kirillova, K. M.,Skvortsova, T. A.,Nikonova, L. Z.,Chugunov, Yu. V.,Igonin, V. B.,Mukhtarov, A. Sh.
, p. 427 - 430 (2007/10/02)
The alkylation of phloroglucinol dialkyl ethers with alcohols or alkyl halides leads, depending on the reaction conditions, either to products of O- or C- alkylation, or to C,O-alkylation products.Reaction conditions were found which enable us to obtain pure phloroglucinol trialkyl ethers.A convenient preparative method for the synthesis of phloroglucinol trialkyl ethers consists in the alkylation of phloroglucinol dialkyl ethers in a two-phase system in presence of phase-transfer catalysts.
