28355-48-8

Basic information

• Product Name: 2-(3-NITROPHENOXY)PYRIDINE 97+%
• Synonyms: 2-(3-NITROPHENOXY)PYRIDINE 97+%;2-(3-NITROPHENOXY)PYRIDINE
• CAS NO: 28355-48-8
• Molecular Formula: C₁₁H₈N₂O₃
• Molecular Weight: 216.19282
• Mol File: 28355-48-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 93-95
• Boiling Point: 347.4 °C at 760 mmHg
• Flash Point: 163.9 °C
• Appearance: /
• Density: 1.309g/cm³
• Vapor Pressure: 0.000108mmHg at 25°C
• Refractive Index: 1.611
• CAS DataBase Reference: 2-(3-NITROPHENOXY)PYRIDINE 97+%(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-NITROPHENOXY)PYRIDINE 97+%(28355-48-8)
• EPA Substance Registry System: 2-(3-NITROPHENOXY)PYRIDINE 97+%(28355-48-8)

Safety Data

• Hazardous Substances Data: 28355-48-8(Hazardous Substances Data)

Usage

Molecular Weight

240.19 g/mol

Purity Level

97% or greater

Chemical Structure

A pyridine ring with a 3-nitrophenoxy group attached at the 2-position.

Classification

Organic compound

Usage

Commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds.

InChI:InChI=1/C11H8N2O3/c14-13(15)9-4-3-5-10(8-9)16-11-6-1-2-7-12-11/h1-8H

Upstream product

• 109-04-6 2-bromo-pyridine 
• 1124-31-8 potassium 4-nitrophenolate 
• 109-09-1 2-chloropyridine 
• 554-84-7 meta-nitrophenol 
• 4783-68-0 2-phenoxypyridine 
• 108-95-2 phenol 
• 142-08-5 2-Pyridone 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 142-08-5 2-hydroxypyridin 

Downstream Products

• 554-84-7 meta-nitrophenol 
• 68716-48-3 4,4,5,5-tetramethyl-2-(3-nitrophenyl)-1,3,2-dioxaborolane 
• 37884-58-5 C,C,C-Trifluoro-N-[3-(pyridin-2-yloxy)-phenyl]-methanesulfonamide 
• 86556-09-4 3-(pyridin-2-yloxy)aniline 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS FOR MODULATING NR2F6

The present disclosure relates to compounds capable of modulating the activity of NR2F6. The compounds of the disclosure may be used in methods for the prevention and/or the treatment of diseases and disorders associated with modulating NR2F6 activity.

2-{2-[3-(Pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl}pyridine: A highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

Structure-activity relationship studies on 3-(5-pyridin-2-yl-2H-tetrazol-2- yl)benzonitrile 2 led to the discovery of 2-{2-[3-(pyridin-3-yloxy)phenyl]-2H- tetrazol-5-yl}pyridine (10)-a highly potent and selective mGlu5 receptor antagonist with good brain penetration and in vivo receptor occupancy in rat and cross-species oral bioavailability. Structure-activity relationship studies on 3-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile 2 led to the discovery of 2-{2-[3-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl}pyridine (10)-a highly potent and selective mGlu5 receptor antagonist with good brain penetration and in vivo receptor occupancy in rat and cross-species oral bioavailability.