28361-44-6

Basic information

• Product Name: 1,2-dimethyl-4-[(4-methylphenyl)sulfonyl]benzene
• Synonyms: 1,2-Dimethyl-4-[(4-methylphenyl)sulfonyl]benzene; 3,4-Dimethylphenyl 4-methylphenyl sulfone; benzene, 1,2-dimethyl-4-[(4-methylphenyl)sulfonyl]-
• CAS NO: 28361-44-6
• Molecular Formula: C₁₅H₁₆O₂S
• Molecular Weight: 260.3513
• Mol File: 28361-44-6.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 421.6°C at 760 mmHg
• Flash Point: 250.9°C
• Density: 1.148g/cm³
• Vapor Pressure: 6.31E-07mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 1,2-dimethyl-4-[(4-methylphenyl)sulfonyl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-dimethyl-4-[(4-methylphenyl)sulfonyl]benzene(28361-44-6)
• EPA Substance Registry System: 1,2-dimethyl-4-[(4-methylphenyl)sulfonyl]benzene(28361-44-6)

Safety Data

• Hazardous Substances Data: 28361-44-6(Hazardous Substances Data)

Usage

General Description

1,2-dimethyl-4-[(4-methylphenyl)sulfonyl]benzene is a chemical compound with the molecular formula C16H18O2S. It is a sulfonyl benzene derivative that consists of a benzene ring with two methyl groups and a sulfonyl group attached at the para position. 1,2-dimethyl-4-[(4-methylphenyl)sulfonyl]benzene is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also utilized in organic chemistry as a reagent for the introduction of sulfonyl groups in target molecules. Additionally, 1,2-dimethyl-4-[(4-methylphenyl)sulfonyl]benzene has potential applications in materials science and as a chemical intermediate in the production of specialty chemicals.

Upstream product

• 340168-09-4 1-((1E,3E,5E)-1-Chloro-5-methyl-hepta-1,3,5-triene-3-sulfonyl)-4-methyl-benzene 
• 95-47-6 o-xylene 
• 104-15-4 toluene-4-sulfonic acid 
• 108-88-3 toluene 
• 583-71-1 4-bromo-o-xylene 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 31599-61-8 3,4-dimethyliodobenzene 
• 55499-43-9 3,4-dimethyl phenylboronic acid 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 38542-71-1 N-methylpyridinium p-toluenesulfonate 
• 139951-30-7 (E)-1-chloro-3-(p-tolylsulfonyl)propene 
• 80-48-8 methyl p-toluene sulfonate 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

TosMIC and its derivatives as versatile sulfonylating agents for the synthesis of p-toluenesulfonylarenes from aryl halides and arylboronic acids

An efficient copper(II) catalyzed sulfonyation of aryl halides has been achieved using TosMIC (p-toluenesulfonylmethyl isocyanide) as a sulfonylating agent. This newly developed sulfonylation approach provides an easy access for the synthesis of diaryl sulfones from aryl bromides, iodides and boronic acids with TosMIC under neutral conditions. This method is useful for the sulfonylation of aryl boronic acids under similar conditions. This is the first report on the sulfonylation of aryl bromides, iodides and boronic acids using TosMIC.

The synthesis of diarylsulfones with simple arenes and K2S2O8 through double C-S bond formation

An unprecedented double C-S bond formation method has been developed to prepare both symmetric and unsymmetric diarylsulfones with simple arenes in a single step. This represents the first example that K2S2O8 can be employed as a highly effective sulfonating agent to synthesize diarylsulfones. The reaction demonstrates excellent reactivity, good functional group tolerance and high yields.

Sulfonylation of aromatic compounds with methyl p-toluenesulfonate as a sulfonylating precursor

We have developed Friedel-Crafts (FC) sulfonylation of aromatic compounds with methyl p-toluenesulfonate as a sulfonylating precursor. In this procedure, methyl p-toluenesulfonate was treated and activated with pyridine to produce N-methylpyridinium p-toluenesulfonate as a sulfonylation reagent. Reactivity of this salt for the sulfonylation of mesitylene was investigated in the presence of three different promoters, such as triflic anhydride, dimethylsulfide ditriflate, and triphenylphosphine ditriflate (TPPD). All of the promoters show chemoselectivity and among them, TPPD presents a chemoselectivity in FC sulfonylation. Iranian Chemical Society 2012.