856865-82-2

Upstream product

• 53793-18-3 (S)-2-(2-nitrophenylsulfonamido)-3-phenylpropanoic acid 
• 74-88-4 methyl iodide 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 16874-17-2 L-phenylalanine tert-butyl ester 
• 63-91-2 L-phenylalanine 
• 845777-57-3 N-(o-nitrobenzenesulfonyl)-N-methyl-L-phenylalanine tert-butyl ester 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 283611-40-5 N-methyl-N-(o-nitrobenzenesulfonyl)-L-phenylalanine methyl ester 
• 203873-67-0 (S)-methyl 2-(2-nitrophenylsulfonamido)-3-phenylpropanoate 

Relevant academic research and scientific papers

Total synthesis of micromide: A marine natural product

This paper describes an efficient procedure for the synthesis of micromide, a natural product that shows anti-solid-tumor activity. Our strategy involved the synthesis of N-nosyl-protected amino acids and their N-methylation with iodo-methane. The hindered oligopeptides containing N-methyl amino acids were synthesized in excellent yields and high purities.[ampi]]

Convenient synthesis of N-methylamino acids compatible with Fmoc solid-phase peptide synthesis

Nα-Methylamino acid containing peptides exhibit interesting therapeutic profiles and are increasingly recognized as potentially useful therapeutics. Unfortunately, their synthesis is hampered by the high price and unavaibility of many Nα/