28368-57-2

Upstream product

• 40489-17-6 2-hydroxypinocembrin 
• 137790-51-3 2-acetyl-3,5-bis(benzyloxy)phenyl benzoate 
• 18065-05-9 1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]ethanone 
• 1646145-95-0 chrysin 6-C-(2''-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside 

Relevant academic research and scientific papers

New flavone C-glycosides from leaves of Sarcotheca griffithii (Hook F) Hallier F

Five new flavone C-glycosides, including chrysin 6-C-(2″-O-α-l- rhamnopyranosyl)-β-d-glucopyranoside (1), chrysin 6-C-(2″-O-α- l-rhamnopyranosyl)-β-d-glucopyranosyl-7-O-β-d-glucopyranoside (2), chrysin 6-C-(2″-O-α-l-rhamnopyranosyl)-6′-deoxy-ribo-hexos-3-

Biosynthesis of natural and novel C-glycosylflavones utilising recombinant Oryza sativa C-glycosyltransferase (OsCGT) and Desmodium incanum root proteins

The rice C-glycosyltransferase (OsCGT) is one of only a small number of characterised plant C-glycosyltransferases (CGT) known. The enzyme C-glucosylates a 2-hydroxyflavanone substrate with UDP-glucose as the sugar donor to produce C-glucosyl-2-hydroxyflavanones. We tested substrate specificity of the enzyme, using synthetic 2-hydroxyflavanones, and showed it has the potential to generate known natural CGFs that have been isolated from rice and also other plants. In addition, we synthesised novel, unnatural 2-hydroxyflavanone substrates to test the B-ring chemical space of substrate accepted by the OsCGT and demonstrated the OsCGT capacity as a synthetic reagent to generate significant quantities of known and novel CGFs. Many B-ring analogues are tolerated within a confined steric limit. Finally the OsCGT was used to generate novel mono-C-glucosyl-2-hydroxyflavanones as putative biosynthetic intermediates to examine the potential of Desmodium incanum biosynthetic CGTs to produce novel di-C-glycosylflavones, compounds implicated in the allelopathic biological activity of Desmodium against parasitic weeds from the Striga genus.