28381-67-1Relevant academic research and scientific papers
Inhibition of carbonic anhydrase isoforms I, II, IV, VII and XII with carboxylates and sulfonamides incorporating phthalimide/phthalic anhydride scaffolds
El-Azab, Adel S.,Abdel-Aziz, Alaa A.-M.,Ayyad, Rezk R.,Ceruso, Mariangela,Supuran, Claudiu T.
, p. 20 - 25 (2016)
We report a panel of carboxylates and sulfonamides incorporating phthalic anhydride and phthalimide moieties in their structure and their interaction with the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). They were synthesized from substituted anthra
The pthaladyns: GTP competitive inhibitors of dynamin I and II GTPase derived from virtual screening
Odell, Luke R.,Howan, Dian,Gordon, Christopher P.,Robertson, Mark J.,Chau, Ngoc,Mariana, Anna,Whiting, Ainslie E.,Abagyan, Ruben,Daniel, James A.,Gorgani, Nick N.,Robinson, Phillip J.,McCluskey, Adam
experimental part, p. 5267 - 5280 (2010/10/18)
We report the development of a homology model for the GTP binding domain of human dynamin I based on the corresponding crystal structure of Dictyostelium discoidum dynamin A. Virtual screening identified 2-[(2-biphenyl-2-yl-1,3-dioxo- 2,3-dihydro-1H-isoin
