28381-92-2

Usage

Uses

Used in Pharmaceutical Industry:
6-PhenylbenziMidazo[1,2-c]quinazoline is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a valuable building block in the development of new drugs with potential therapeutic applications.
Used in Polymer Industry:
6-PhenylbenziMidazo[1,2-c]quinazoline is used as a monomer in the preparation of polymers. Its incorporation into polymer chains can enhance the properties of the resulting materials, such as their mechanical strength, thermal stability, and chemical resistance. This makes it a valuable component in the development of advanced polymers for various applications, including automotive, aerospace, and electronics industries.
Used in Chemical Research:
6-PhenylbenziMidazo[1,2-c]quinazoline is also used as a research tool in the field of organic chemistry. Its unique structure and properties make it an interesting subject for studying various chemical reactions and mechanisms, which can lead to the discovery of new synthetic methods and applications.

Upstream product

• 5805-39-0 2-(aminophenyl)benzimidazole 
• 98-88-4 benzoyl chloride 
• 2208-58-4 2-(2-nitrophenyl)-1H-benzimidazole 
• 100-46-9 benzylamine 
• 1663-61-2 triethoxymethylbenzene 
• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 
• 95-54-5 1,2-diamino-benzene 
• 76244-62-7 3-(2-aminophenyl)-2-phenylquinazolin-4(3H)-one 
• 57427-78-8 (4Z)-4-(4-methoxybenzylidene)-2-phenyl-oxazolin-5-one 
• 54559-57-8 N-[2-(1H-benzimidazol-2-yl)phenyl]benzamide 
• 681453-65-6 1-benzoyl-2-(2-nitrophenyl)-1H-benzimidazole 
• 118-92-3 anthranilic acid 
• 1170949-89-9 N-[2-(1H-benzo[d]imidazol-2-yl)phenyl]-N-[(E)-1-phenylmethylidene]amine 
• 3574-96-7 2-(2-chlorophenyl)-1H-benzimidazole 

Relevant academic research and scientific papers

Rhodium(III)-catalyzed [4?+?2] annulation of N-arylbenzamidines with 1,4,2-dioxazol-5-ones: Easy access to 4-aminoquinazolines via highly selective C[sbnd]H bond activation

A novel approach for the synthesis of 4-aminoquinazolines has been developed via rhodium(III)-catalyzed [4 + 2] annulation of N-arylbenzamidines with 1,4,2-dioxazol-5-ones. This reaction features excellent regioselectivity, broad substrate scope and high step economy, which would provide the reference for the construction of the fused 4-aminoquinazolines with biologically and pharmacologically active compounds.

Application of Aza-type iso-cryptolepine derivatives in prevention and treatment of agricultural plant diseases

The invention discloses application of any compound of Aza-type iso-cryptolepine derivatives A0-A38 in prevention and treatment or resisting of agricultural plant diseases. Antibacterial activity testresults show that the compounds have certain inhibitory

Rh(III)-Catalyzed One-Pot Synthesis of Benzimidazoquinazolines via C-H Amidation-Cyclization of N-LG-2-phenylbenzoimidazoles

An efficient protocol to synthesize substituted benzo[4,5]imidazo[1,2-c]quinazolines starting from N-LG-2-phenylbenzoimidazole and dioxazolones catalyzed by Rh(III) or Ir(III) has been developed. Various substituted benzo[4,5]imidazo[1,2-c]quinazolines co

Design, synthesis and antifungal activity evaluation of isocryptolepine derivatives

In this paper, the nitrogen atom was inserted into the anthracycline system of the isocryptolepine nucleus to obtain the “Aza”-type structure benzo[4,5]imidazo[1,2-c] quinazoline. A series of “Aza”-type derivatives were designed, synthesized and evaluated for their antifungal activity against six plant fungi in vitro. Among all derivatives, compounds A-0, B-1 and B-2 showed significant antifungal activity against B. cinerea with the EC50 values of 2.72 μg/mL, 5.90 μg/mL and 4.00 μg/mL, respectively. Compound A-2 had the highest activity against M. oryzae with the EC50 values of 8.81 μg/mL, and compound A-1 demonstrated the most control efficacy against R. solani (EC50, 6.27 μg/mL). Moreover, compound A-0 was selected to investigate the in vivo tests against B. cinerea and the results indicated that the preventative efficacy of it up to 72.80% at 100 μg/mL. Preliminary mechanism studies revealed that after treatment with A-0 at 5 μg/mL, the B. cinerea mycelia appeared curved, collapsed and the cell membrane integrity may be damaged. The reactive oxygen species production, mitochondrial membrane potential and nuclear morphometry of mycelia have been changed, and the membrane function and cell proliferation of mycelia were destroyed. Compounds A-0, A-1, B-1 and B-2 presented weaker toxicities against two cells lines than isocryptolepine. This study lays the foundation for the future development of isocryptolepine derivatives as environmentally friendly and safe agricultural fungicides.

Synthetic method of benzimidazole [1,2-c] quinazolines compound

The invention belongs to the technical field of synthesis of compounds, and particularly relates to a synthetic method of a benzimidazole [1,2-c] quinazolines compound. The synthetic method of the benzimidazole [1,2-c] quinazolines compound comprises the following steps: under the condition of alkalinity, assisting in copper to catalyzing 2-(2-halo phenyl) benzimidazole and primary amine at firstby using ultraviolet light to carry out Uhlmann coupling reaction; and then carrying out oxidized ring closure and oxidized dehydrogenation by using oxygen as an oxidizing agent to form the benzimidazole [1,2-c] quinazolines compound. The method is carried out at a room temperature, wherein the molar ratio of 2-(2-halo phenyl) benzimidazole, alkali and amine is 1: 3: (1-3), and the use amount of acopper catalyst is 20 mmol%. Iodobenzene with high activity is used in photocatalyzed Uhlmann N-arylation of aryl halide in the prior art, moreover, reports for carbon-hydrogen bond ammonium oxide are finished under the condition of heating, and furthermore, benzylamines are used. Photocatalyzed Uhlmann N-arylation of aryl chloride and aryl fluoride is broken through; and moreover, carbon-hydrogen bond oxidation and amination reaction of photocatalyzed non-benzylamine aliphatic amines are also broken through.

Rh-Catalyzed Annulation of ortho-C?H Bonds of 2-Arylimidazoles with 1,4,2-Dioxazol-5-ones toward 5-Arylimidazo[1,2-c]quinazolines

A Rh-catalyzed unique and direct approach for constructing a series of 5-arylimidazo[1,2-c]quinazolines in moderate to excellent yields from simple and readily available 2-arylimidazoles and 3-phenyl-1,4,2-dioxazol-5-ones was described. This procedure pro

Amidinyl Radical Formation through Anodic N?H Bond Cleavage and Its Application in Aromatic C?H Bond Functionalization

We report herein an atom-economical and sustainable approach to access amidinyl radical intermediates through the anodic cleavage of N?H bonds. The resulting nitrogen-centered radicals undergo cyclizations with (hetero)arenes, followed by rearomatization,

Copper-mediated aerobic oxidative synthesis of benzimidazo fused quinazolines via a multicomponent approach

The first copper mediated aerobic oxidative multi-component synthesis of benzimidazo[1,2-c]quinazolines has been developed from 2-(2-halophenyl)benzoimidazoles, aldehydes and sodium azide as a nitrogen source. This protocol involves the formation of three

General and efficient copper-catalyzed aerobic oxidative synthesis of N-fused heterocycles using amino acids as the nitrogen source

A general and efficient copper-catalyzed aerobic oxidative method for the synthesis of N-fused heterocycles has been developed by using readily available α-amino acids as the nitrogen source. The reactions underwent N-arylation, aerobic oxidative dehydrogenation, intramolecular cyclization and dissociation of formic acid. This method should provide a general and practical strategy for the construction of N-fused heterocycles.

Copper-catalyzed sequential Ullmann N-arylation and aerobic oxidative C-H amination: A convenient route to indolo[1,2-c]quinazoline derivatives

An efficient synthesis of indolo[1,2-c]quinazoline derivatives has been developed by copper-catalyzed sequential Ullmann N-arylation and aerobic oxidative C-H amination. The protocol uses readily available 2-(2-halophenyl)-1H-indoles and (aryl)methanamines as the starting materials to afford indolo[1,2-c]quinazolines, which are the core units of hinckdentine A.