28384-61-4

Usage

Uses

Used in the Paint and Coating Industry:
N-N-BUTYL METHACRYLAMIDE is used as a key ingredient in the production of water-based paints, adhesives, and coatings, enhancing their performance and durability.
Used in the Textile and Paper Industry:
In these industries, N-N-BUTYL METHACRYLAMIDE serves as a crosslinking agent, improving the strength and quality of textiles and paper products.
Used in the Manufacturing of Specialty Polymers and Resins:
N-N-BUTYL METHACRYLAMIDE is employed as a component in the synthesis of specialty polymers and resins, which are used in various applications due to their unique properties.
Used in the Medical Field:
N-N-BUTYL METHACRYLAMIDE is used as a component in the development of biocompatible polymers and hydrogels, which have potential applications in medical devices, drug delivery systems, and tissue engineering.

InChI:InChI=1/C8H15NO/c1-4-5-6-9-8(10)7(2)3/h2,4-6H2,1,3H3,(H,9,10)

Upstream product

• 109-73-9 N-butylamine 
• 80-62-6 methacrylic acid methyl ester 
• 920-46-7 Methacryloyl chloride 

Downstream Products

• 180183-00-0 (2R,3S,5S)-2-[3-(tert-butoxycarbonyl)amino-5-(benzyloxymethyl)-2-hydroxy-6-methylheptyl]-N-(butyl)acrylamide 
• 180182-99-4 (2S,3S,5S)-2-[3-(tert-butoxycarbonyl)amino-5-(benzyloxymethyl)-2-hydroxy-6-methylheptyl]-N-(butyl)acrylamide 
• 173007-38-0 C₃₁H₅₂N₂O₄ 
• 172900-95-7 N-tert-butoxycarbonyl-2-methylene-4(S)-hydroxy-5(S)-amino-7(S)-isopropyl-8-(p-tert-butyl-phenyl)-octanoic acid (N-butyl) amide 
• 1309763-10-7 1-n-butyl-3-methyl-5,6-diphenylpyridin-2(1H)-one 

Relevant academic research and scientific papers

Effect of Transition Metals on Chemodivergent Cross-Coupling of Acrylamides with Vinyl Acetate via C-H Activation

A novel chemodivergent cross-coupling of acrylamides and vinyl acetates has been realized via metal-catalyzed vinylic C-H activation. The selective olefinic C-H vinylation and alkenylation reaction was examined with a variety of differently functionalized acrylamides. The reaction efficiently generates a range of highly synthetically valuable butadienes with good functional group tolerance in good to moderate yields. A possible catalytic reaction mechanism involving the chelation-assisted olefinic C-H activation via an acetate-assisted deprotonation pathway is proposed.

Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl- octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin

The action of renin is the rate-limiting step of the renin-angiotensin system (RAS), a key regulator of blood pressure. Effective renin inhibitors directly block the RAS entirely at source and, thus, may provide a vital weapon for hypertension therapy. Our efforts toward identifying novel small-molecule peptidomimetic renin inhibitors have resulted in the design of transition-state isosteres such as 1 bearing an all-carbon 8-phenyl-octanecarboxamide framework. Optimization of the extended P3 portion of 1 and extensive P2′ modifications provided analogues with improved in vitro potencies in the presence of plasma. X-ray resolution of rh-renin/38a in the course of SAR work surprisingly unveiled the exploitation of a previously unexplored pocket (S3sp) important for strong binding affinities. Several inhibitors demonstrated oral efficacy in sodium-depleted marmosets. The most potent, 38a, induced dose-dependently a pronounced reduction in mean arterial blood pressure, paralleled by complete blockade of active plasma renin, up to 8 h post-dose. Oral bioavailability of 38a was 16% in marmosets.

Lipase catalyzed aminolysis of ethyl propiolate and acrylic esters. Synthesis of chiral acrylamides

Candida cylindracea lipase is a useful catalyst for the preparation of propiolamides. Candida antarctica lipase efficiently catalyzes the aminolysis of different acrylic esters and aliphatic amines; if racemic amines are used, the corresponding optically active acrylic amide is obtained in moderate-high enantiomeric excess.