N-Butylmethacrylamide

Base Information

• Chemical Name: N-Butylmethacrylamide
• CAS No.: 28384-61-4
• Molecular Formula: C8H15NO
• Molecular Weight: 141.213
• Hs Code.: 2924199090
• DSSTox Substance ID: DTXSID50431800
• Nikkaji Number: J800.005K
• Wikidata: Q82245775
• Mol file: 28384-61-4.mol

Synonyms:N-BUTYLMETHACRYLAMIDE;28384-61-4;N-N-Butyl methacrylamide;N-butyl-2-methylprop-2-enamide;butyl methacrylamide;Methacrylamide, N-butyl-;methacrylic acid butylamide;SCHEMBL27247;DTXSID50431800;MFCD00048754;AKOS006345199;BS-49265;CS-0188272;FT-0650930;A20600

Chemical Property of N-Butylmethacrylamide

Chemical Property:

• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.437
• Boiling Point: 265.376 °C at 760 mmHg
• Flash Point: 150.548 °C
• PSA: 29.10000
• Density: 0.875 g/cm³
• LogP: 1.86970
• Storage Temp.: 2-8°C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 141.115364102
• Heavy Atom Count: 10
• Complexity: 129

Purity/Quality:

98%min ^*data from raw suppliers

N-Butylmethacrylamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCNC(=O)C(=C)C

Technology Process of N-Butylmethacrylamide

There total 4 articles about N-Butylmethacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-butylamine (109-73-9,85404-21-3) + Methacryloyl chloride (920-46-7,26937-45-1) → methacrylic acid N-(butyl)amide (28384-61-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; hydroquinone; In toluene; at 10 - 15 ℃; for 4h;

DOI:10.1021/jm070314y

Reference yield: 81.0%

N-butylamine (109-73-9,85404-21-3) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → methacrylic acid N-(butyl)amide (28384-61-4)

Guidance literature:

In di-isopropyl ether; at 30 ℃; for 144h; Candida antarctica lipase (CAL);

DOI:10.1016/S0040-4020(01)89914-2

Reference yield:

→ methacrylic acid N-(butyl)amide (28384-61-4)

Guidance literature:

With aluminum oxide; at 325 ℃;

upstream raw materials:

N-butylamine

methacrylic acid methyl ester

Methacryloyl chloride

Downstream raw materials:

N-tert-butoxycarbonyl-2-methylene-4(S)-hydroxy-5(S)-amino-7(S)-isopropyl-8-(p-tert-butyl-phenyl)-octanoic acid (N-butyl) amide

Refernces

• 1、 G?schke, Richard,Stutz, Stefan,Rasetti, Vittorio,Cohen, Nissim-Claude,Rahuel, Joseph,Rigollier, Pascal,Baum, Hans-Peter,Forgiarini, Peter,Schnell, Christian R.,Wagner, Trixie,Gruetter, Markus G.,Fuhrer, Walter,Schilling, Walter,Cumin, Frédéric,Wood, Jeanette M.,Maibaum, Jürgen. "Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl- octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin". . p. 4818 - 4831. Retrieved 2008/03/13.