284031-80-7

Basic information

• Product Name: 1-[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]-4-methylbenzene
• Synonyms: 1-[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]-4-methylbenzene
• CAS NO: 284031-80-7
• Molecular Weight: 240.677
• Mol File: 284031-80-7.mol

Chemical Properties

• CAS DataBase Reference: 1-[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]-4-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]-4-methylbenzene(284031-80-7)
• EPA Substance Registry System: 1-[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]-4-methylbenzene(284031-80-7)

Safety Data

• Hazardous Substances Data: 284031-80-7(Hazardous Substances Data)

Upstream product

• 306-83-2 1,1,1-trifluoro-2,2-dichloroethane 
• 106-45-6 para-thiocresol 
• 151-67-7 1,1,1-trifluoro-2-bromo-2-chloroethane 

Downstream Products

• 103-19-5 di(p-tolyl) disulfide 
• 62158-92-3 (2,2,2-trifluoroethyl) (4-methylphenyl) sulfide 
• 284031-83-0 1,1,1-trifluoro-2-(4-methylbenzenesulfonyl)ethane 

Relevant articles and documents

Insight into "entrainment" in SRN1 reactions of 2,2-dichloro-1,1,1-trifluoroethane(HCFC-123) with thiolates initiated by Na2S2O4

An interesting entrainment process in SRN1 reactions of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123) with thiolates were studied by experiments and DFT calculations. The radical-anion intermediate, generated from coupling of the fluorinated ra

Copper-mediated radical cross-coupling reaction of 2,2-dichloro-1,1,1- trifluoroethane (HCFC-123) with phenols or thiophenols

A copper-mediated cross-coupling reaction between HCFC-123 and phenols or thiophenols has been achieved. It is found that diethyl amine, which serves as both the activator and ligand of copper, plays a key role in this reaction. Two possible radical involved processes are proposed for the reaction mechanism.

A facile synthesis of 1-chloro-2,2,2-trifluoroethyl sulfides

A facile synthesis of structurally diverse 1-chloro-2,2,2-trifluoroethyl sulfides from readily available 1-bromo-1-chloro-2,2,2-trifluoroethane (Halothane) and various aliphatic and aromatic thiols in the presence of sodium dithionite/sodium bicarbonate is described. The synthetic utility of the prepared sulfides is illustrated by the synthesis of biologically potent heterocycles and by their electrophilic reactions with thiophene.

Synthesis of new synthons for organofluorine compounds from Halothane containing sulfur functional groups

To develop new synthons for the syntheses of organofluorine compounds, the treatment of Halothane, 2-bromo-2-chloro-1,1,1-trifluoroethane, (1) with 4-methylbenzenethiol (2) in the presence of sodium hydride gave 1-chloro- 2,2,2-trifluoroethyl 4-methylphenyl sulfide (3), which was oxidized with m- chloroperbenzoic acid (m-CPBA) to the corresponding sulfoxide (4) and sulfone (5). Reaction of 3 and 5 with allyltributyltin in the presence of 2,2'- azobis(isobutyronitrile) (AIBN) gave 1-(trifluoromethyl)-3-butenyl compounds (9, 11). Sulfoxide 4 was decomposed in this condition. The treatment of 3 with allyltrimethylsilane in the presence of Lewis acids gave 1- (trifluoromethyl)-3-butenyl compounds (9) in good yield. This result suggests that 4-methylphenylthio substituent stabilizes the α-carbocation effectively, though the trifluoromethyl group destabilizes it strongly. Aromatic compounds similarly reacted with 3 in the presence of titanium(IV) chloride to give 2-aryl-1,1,1-trifluoro-2-(4-methylphenylthio)ethanes. Thus, sulfur compounds derived from Halothane were found to be useful new synthons for organofluorine compounds.