284044-47-9

Basic information

• Product Name: benzyl 2-benzoyl-2-tert-butylhydrazinecarboxylate
• Synonyms: benzyl 2-benzoyl-2-tert-butylhydrazinecarboxylate
• CAS NO: 284044-47-9
• Molecular Formula: C₁₉H₂₂N₂O₃
• Molecular Weight: 326.38958
• Mol File: 284044-47-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: benzyl 2-benzoyl-2-tert-butylhydrazinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 2-benzoyl-2-tert-butylhydrazinecarboxylate(284044-47-9)
• EPA Substance Registry System: benzyl 2-benzoyl-2-tert-butylhydrazinecarboxylate(284044-47-9)

Safety Data

• Hazardous Substances Data: 284044-47-9(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 501-53-1 benzyl chloroformate 
• 60103-94-8 N-tert-butyl-N’-benzyloxycarbonylhydrazide 
• 98-88-4 benzoyl chloride 

Downstream Products

• 403739-80-0 C₂₀H₂₅N₃O₂ 
• 403739-79-7 C₁₈H₁₉Cl₂N₃O₂ 
• 403739-77-5 C₁₈H₂₀FN₃O₂ 
• 403739-78-6 C₁₉H₂₃N₃O₃ 
• 403739-88-8 C₁₈H₂₀ClN₃O₂ 
• 403739-76-4 C₁₈H₂₁N₃O₂ 
• 99981-48-3 N'-t-butyl-N'-benzoylhydrazine 

Relevant articles and documents

A Convenient Synthesis of Novel N′-tert-Butyl-N′-Substituted Benzoyl-N-(Substituted Phenyl)aminocarbonylhydrazines and Their Derivatives

N-tert-butyl-N-substituted benzoylhydrazines were prepared in two convenient procedures with good yields, subsequent reaction with substituted phenylisocyanates in 1,2-dichloroethane provided a series of novel N′-tert-butyl-N‰-substituted benzoyl-N-(substituted phenyl)aminocarbonylhydrazines. Further treatment with oxalyl chloride gave their derivatives in good yields. The title compounds exhibit moderate larvicidal activities and anticancer activities.

Synthesis and biological activity of novel N′-tert-butyl-N′-substituted benzoyl-N-(substituted phenyl)aminocarbonylhydrazines and their derivatives

Benzyl chloroformate was synthesised by the reaction of benzyl alcohol and triphosgene in good yield for the first time. N-tert-Butyl-N-substituted benzoylhydrazines were prepared in a new and convenient procedure with good yields. A series of novel N′-tert-butyl-N′-substituted benzoyl-N-(substituted phenyl)aminocarbonylhydrazines and their derivatives were synthesised and evaluated for molting hormone mimicking activity. The results of bioassays showed that the title compounds exhibit good larvicidal activities and toxicity assays indicated that the title compounds can induce a premature, abnormal and lethal larval molt. We have found that the title compounds possess potential anticancer activities.

Condensation reaction of 1-oxo-4-chlorocarbonyl-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane with N-t-butyl-N-benzoylhydrazine

1-Oxo-4-chlorocarbonyl-l-phospha-2,6,7-trioxabicyclo[2.2.2]octane (5) was obtained from phosphorus oxychloride. Benzyl chloroformate was synthesized by the reaction of benzyl alcohol and triphosgene in good yield for the first time. N-t-Butyl-N-benzoylhydrazine (11) was prepared in a new and convenivent procedure with good yield. The reaction of 5 and 11 proceeded smoothly in the presence of sodium carbonate and afforded the desired compound 13 in good yield, while in the presence of triethylamine, the elimination of butyl was observed and afforded the compound 12.