28443-57-4

Usage

Uses

Used in Hair Dye and Colorant Production:
2-Amino-4,5-dichlorophenol is utilized as a key ingredient in the production of hair dyes and colorants. Its chemical properties allow for the creation of a variety of shades and hues, making it a valuable component in the cosmetics industry.
Used in Pharmaceutical Research:
2-Amino-4,5-dichlorophenol has been studied for its potential use in pharmaceuticals. Its unique structure and reactivity make it a candidate for the development of new drugs, although further research is necessary to fully understand its therapeutic potential and safety profile.
Used as an Intermediate in Organic Synthesis:
2-Amino-4,5-dichlorophenol also serves as an intermediate in organic synthesis, contributing to the formation of more complex molecules and compounds. Its presence in various chemical reactions highlights its versatility in the field of organic chemistry.
Used in Chemical Research:
Due to its unique structure, 2-Amino-4,5-dichlorophenol is also used in chemical research to study the effects of substituents on the properties and reactivity of phenol derivatives. This helps in understanding the fundamental principles of organic chemistry and can lead to the discovery of new applications and uses for 2-Amino-4,5-dichlorophenol.

InChI:InChI=1/C6H5Cl2NO/c7-3-1-5(9)6(10)2-4(3)8/h1-2,10H,9H2

Upstream product

• 39224-65-2 2-nitro-4,5-dichlorophenol 
• 116278-64-9 C₁₁H₁₃Cl₂NO₂ 
• 6306-39-4 1,2-dichloro-4,5-dinitrobenzene 
• 95-77-2 3,4-dichlorophenol 

Downstream Products

• 99357-02-5 N-(4,5-dichloro-2-hydroxy-phenyl)-N'-(3,4-dichloro-phenyl)-urea 
• 96460-31-0 N-(4-chloro-phenyl)-N'-(4,5-dichloro-2-hydroxy-phenyl)-thiourea 
• 96462-09-8 N-(4,5-dichloro-2-hydroxy-phenyl)-N'-(3,4-dichloro-phenyl)-thiourea 
• 93567-32-9 5,6-dichloro-2-(4-methoxy-phenyl)-benzooxazole 
• 28443-58-5 N-(4,5-dichloro-2-hydroxyphenyl)acetamide 
• 71865-29-7 5,6-dichlorobenzoxazole-2-thione 
• 921198-81-4 N-(4,5-dichloro-2-hydroxyphenyl)-4-nitrobenzamide 
• 945374-90-3 N-(3,4-dichloro-6-oxocyclohexa-2,4-dienylidene)-4-nitrobenzamide 
• 921198-78-9 (R)-6,7-dichloro-3-isobutyl-4-(4-nitrobenzoyl)-3,4-dihydrobenzo[b][1,4]oxazin-2-one 
• 921198-93-8 (R)-methyl 2-(N-(4,5-dichloro-2-hydroxyphenyl)-4-nitrobenzamido)-3-phenylpropanoate 

Relevant academic research and scientific papers

ANTIBIOTIC COMPOUNDS

The present invention relates to antibiotic compounds of formula (I), to compositions containing these compounds and to methods of treating bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Gram-positive and/or Gram-negative bacteria, and in particular in the treatment of infection with, and diseases caused by, Neisseria gonorrhoeae.

COVALENT INHIBITORS OF KRAS G12C

Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods of treatment of disorders mediated by G12C mutant K-Ras protein.

Synthesis and in vitro antimycobacterial and isocitrate lyase inhibition properties of novel 2-methoxy-2′-hydroxybenzanilides, their thioxo analogues and benzoxazoles

A new series of 2-methoxy-2′-hydroxybenzanilide derivatives and their thioxo analogues have been synthesised and characterised by IR, NMR and elemental analysis. These compounds were investigated for their in vitro antimycobacterial activities against Mycobacterium tuberculosis 331/88, Mycobacterium avium 330/88, Mycobacterium kansasii 235/80, clinically isolated M. kansasii 6509/96 and the ability to act as in vitro isocitrate lyase inhibitors. The best ICL inhibitors were two compounds from the thiobenzanilide group (8f, 8m), which exhibited an inhibition potential that was equal to the standard compound, 3-nitropropionic acid. In addition, the best antimycobacterial properties were exhibited by benzanilide derivatives 6h, 6k and 6l with 5-Cl and 4′ or 5′ Cl/Br substitution. For all the thiobenzanilide derivatives tested, two conformers were observed in the NMR spectra, which is most likely due to the hindered rotation of the C-N bond.

Facile rearrangements of alkynylamino heterocycles with noble metal cations

A number of 2-(alkynylamino)-substituted heterocycles have been synthesized. These heterocycles rearrange in the presence of silver(I) and gold(I) salts to give novel 2H-pyrimido[2,1-b]benzoxazoles, 2H-pyrimido[2,1-b]benzothiazoles, and a 2H-pyrimido[2,1-b]benzoselenazole. Two of the the 2H-pyrimido[2,1-b]benzoxazoles were isolated in good yield. The kinetics of the silver tetrafluoroborate-catalyzed rearrangements of selected (alkynylamino)benzoxazoles and benzothiazoles have been examined by 1H NMR in CD3CN. Factors affecting the electron densities of the triple bond and of the nitrogen atom in the heterocycle are important in influencing the rate of rearrangement.

Hydrolysis and Fe2+-induced Reduction of N-Aryl -O-pivaloylhydroxylamines: Aqueous Solution Chemistry of Model Carcinogens.

The N-aryl-O-pivaloylhydroxylamines, 1a-d, which serve as models for the carcinogenic metabolites of aromatic amines, decompose in aqueous media by heterolysis of the N-O bond.Substituent effects on rates of reaction and products of the decomposition of 1a-c are entirely consistent with the intermediacy of a singlet nitrenium ion.The least reactive compound in the series N-(4-nitrophenyl)-O-pivaloylhydroxylamine (1d) yields 4-nitroaniline (2d) as its major decomposition product.This material may be formed through H radical abstraction by a triplet ion, but a nitrene reaction appears to be more likely.In the presence of Fe2+ 1a-d undergo rapid reduction to the corresponding anilines 2a-d.This reaction requires complexation of the ester with Fe2+ and proceeds with heterolysis of the N-O bond since nearly quantitative yields of pivalic acid are isolated.The radical cations 25a-d appear to be the most likely precursors to the reduction products.

Lipogenesis control by esters of benzoxazinecarboxylic acids

Lipogenesis in mammals is inhibited by esters of 3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acids.

Thieno[3,4-b][1,5]benzoxazepin-10-ones and thieno[3,4-b][1,5]benzothiazepin-10-ones

This disclosure describes novel substituted thieno[3,4-b][1,5]benzoxazepin-10 (9H)-ones and thieno[3,4-b][1,5]benzothiazepin-10(9H)-ones which are useful as intermediates for the preparation of 10-[4-(substituted)-1-piperazinyl]thieno[3,4-b][1,5]benzoxaze