39224-65-2

Basic information

• Product Name: 4,5-DICHLORO-2-NITROPHENOL
• Synonyms: 4,5-Dichloro-2-nitrophenol 98%;Phenol, 4,5-dichloro-2-nitro-
• CAS NO: 39224-65-2
• Molecular Formula: C₆H₃Cl₂NO₃
• Molecular Weight: 208
• Mol File: 39224-65-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 82-82.5℃
• Boiling Point: 274°Cat760mmHg
• Flash Point: 119.5°C
• Appearance: /
• Density: 1.682g/cm³
• Vapor Pressure: 0.00332mmHg at 25°C
• Refractive Index: 1.638
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 5.31±0.27(Predicted)
• CAS DataBase Reference: 4,5-DICHLORO-2-NITROPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DICHLORO-2-NITROPHENOL(39224-65-2)
• EPA Substance Registry System: 4,5-DICHLORO-2-NITROPHENOL(39224-65-2)

Safety Data

• Hazardous Substances Data: 39224-65-2(Hazardous Substances Data)

Usage

Uses

4,5-Dichloro-2-nitrophenol is used in the synthesis of dimethylpropanthioates as CETP inhibitors. Also used in the improved synthesis of hydroxyindoles.

InChI:InChI=1/C6H3Cl2NO3/c7-3-1-5(9(11)12)6(10)2-4(3)8/h1-2,10H

Upstream product

• 89-69-0 2,4,5-Trichloronitrobenzene 
• 99-54-7 3,4-dichloronitrobenzene 
• 95-77-2 3,4-dichlorophenol 
• 6306-39-4 1,2-dichloro-4,5-dinitrobenzene 

Downstream Products

• 1413929-90-4 C₁₄H₁₀Cl₃NO₂S 
• 1413930-05-8 C₁₄H₈Cl₃NO₂ 
• 1413929-83-5 C₁₄H₁₀Cl₃NO₂S 
• 1413930-00-3 C₁₄H₈Cl₃NO₂ 
• 1413929-68-6 C₁₄H₁₀Cl₃NO₃ 
• 1413929-97-1 C₂₂H₁₅Cl₄NO₅ 
• 100948-84-3 1,2-dichloro-4-methoxy-5-nitrobenzene 
• 71865-29-7 5,6-dichlorobenzoxazole-2-thione 
• 783288-19-7 S-[4,5-dichloro-2-(1-isopentylcyclohexanecarbonylamino)phenyl]N,N-dimethylthiocarbamate 

Relevant articles and documents

The reaction of 1,2-dichloro-4,5-dinitrobenzene with hydroxide ion: Roles of meisenheimer complexes and radical pairs

The reaction of 1,2-dichloro-4,5-dinitrobenzene (DCDNB) with aqueous OH- produces (after acidification) 2-nitro-4,5-dichlorophenol with loss of NO 2. Nevertheless, with > 2 mol L-1 OH-, only DCDNB was recovered due to the

COVALENT INHIBITORS OF KRAS G12C

Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods of treatment of disorders mediated by G12C mutant K-Ras protein.

HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl

Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division, also are disclosed.