71865-29-7

Basic information

• Product Name: 5,6-Dichloro-2(3H)-benzoxazolethione
• Synonyms: 5,6-Dichloro-2(3H)-benzoxazolethione;5,6-Dichloro-3H-benzooxazole-2-thione
• CAS NO: 71865-29-7
• Molecular Formula: C7H3Cl2NOS
• Molecular Weight: 220.07582
• Product Categories: Aromatics, Miscellaneous Reagents
• Mol File: 71865-29-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 221-223 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Boiling Point: 318.7±52.0 °C(Predicted)
• Appearance: /
• Density: 1.70±0.1 g/cm3(Predicted)
• PKA: 9.41±0.20(Predicted)
• CAS DataBase Reference: 5,6-Dichloro-2(3H)-benzoxazolethione(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-Dichloro-2(3H)-benzoxazolethione(71865-29-7)
• EPA Substance Registry System: 5,6-Dichloro-2(3H)-benzoxazolethione(71865-29-7)

Safety Data

• Hazardous Substances Data: 71865-29-7(Hazardous Substances Data)

Usage

Uses

5,6-Dichloro-2(3H)-benzoxazolethione is used in the synthesis of mPGES-1 inhibitors.

Upstream product

• 75-15-0 carbon disulfide 
• 28443-57-4 2-amino-4,5-dichlorophenol 
• 39224-65-2 2-nitro-4,5-dichlorophenol 
• 95-77-2 3,4-dichlorophenol 
• 140-89-6 potassium ethyl xanthogenate 
• 5285-41-6 5,6-dichloro-3H-1,3-benzoxazol-2-one 

Downstream Products

• 1421257-32-0 C₂₀H₂₅Cl₂N₃O₃ 

Relevant articles and documents

ANTIBIOTIC COMPOUNDS

The present invention relates to antibiotic compounds of formula (I), to compositions containing these compounds and to methods of treating bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Gram-positive and/or Gram-negative bacteria, and in particular in the treatment of infection with, and diseases caused by, Neisseria gonorrhoeae.

Facile rearrangements of alkynylamino heterocycles with noble metal cations

A number of 2-(alkynylamino)-substituted heterocycles have been synthesized. These heterocycles rearrange in the presence of silver(I) and gold(I) salts to give novel 2H-pyrimido[2,1-b]benzoxazoles, 2H-pyrimido[2,1-b]benzothiazoles, and a 2H-pyrimido[2,1-b]benzoselenazole. Two of the the 2H-pyrimido[2,1-b]benzoxazoles were isolated in good yield. The kinetics of the silver tetrafluoroborate-catalyzed rearrangements of selected (alkynylamino)benzoxazoles and benzothiazoles have been examined by 1H NMR in CD3CN. Factors affecting the electron densities of the triple bond and of the nitrogen atom in the heterocycle are important in influencing the rate of rearrangement.