28467-42-7

Upstream product

• 28467-41-6 cis-4-tert-butylcyclohexanecarboxylic acid chloride 
• 98-52-2 4-(1,1-dimethylethyl)-cyclohexanol 
• 943-29-3 trans-4-(tert-butyl)cyclohexane-1-carboxylic acid 

Downstream Products

• 907-04-0 bis-(trans-4-tert-butyl-cyclohexanecarbonyl)-peroxide 
• 1514926-87-4 (trans)-4-(tert-butyl)-N-(quinolin-8-yl)cyclohexane-1-carboxamide 
• 28125-17-9 methyl trans-(4-t-butylcyclohexyl)acetate 
• 28125-18-0 trans-4-tert-butylcyclohexylacetic acid 
• 28125-22-6 1-(4-tert-Butyl-cyclohexyl)-propan-2-ol 
• 28125-19-1 1-(4-tert-Butyl-cyclohexyl)-propan-2-one 
• 28112-58-5 trans-4-tert-Butylcyclohexylphenylmethanol 
• 28112-56-3 trans-(4-tert-Butylcyclohexyl)phenylketon 
• 28125-13-5 1-(4-tert-Butyl-cyclohexyl)-2-diazo-ethanone 

Relevant academic research and scientific papers

Palladium-Catalyzed Migratory Insertion of Carbenes and C-C Cleavage of Cycloalkanecarboxamides

A palladium catalyzed reaction of cycloalkanecarboxamides and diazomalonates or bis(phenylsulfonyl)diazomethane has been developed. The reaction proceeds via carbene migratory insertion and cascade C-C cleavage pathways. Cycloalkanecarboxamides with four to seven membered rings are applicable in the transformation. A series of ring opening products were prepared with moderate yields. The finding provides valuable clues for the development of new reactions involving carbene migratory insertion and the cleavage of unstrained C(sp3)-C(sp3) bonds.

Pd(II)-Catalyzed Enantioselective C(sp3)-H Borylation

Pd(II)-catalyzed enantioselective borylation of C(sp3)-H bonds has been realized for the first time using chiral acetyl-protected aminomethyl oxazoline ligands. This reaction is compatible with carbocyclic amides containing α-tertiary as well as α-quaternary carbon centers. The chiral β-borylated amides are useful synthons for the synthesis of chiral β-hydroxylated, β-fluorinated, and β-arylated carboxylic acids.

Containing halogenated phenyl trans-cyclohexane amide compound and use thereof

The invention relates to the field of thrombotic disease related medicines. Specifically, the invention relates to a trans-cyclohexane amide structured PAR-1 antagonist containing structures, such as halogenated phenyl and the like, a preparation method of the antagonist and application of the antagonist in preparation of medicines for treating thrombotic diseases, wherein R is selected from C1-C3 alkyl, C3-C5 cycloalkyl and halogen substituent.

A trans-cyclohexane amide compound and use thereof

The invention relates to the field of medicines related to thrombotic diseases and in particular relates to PAR-1 (protease activated receptors-1) antagonists containing trans-cyclohexane amide structures shown in a formula (I) and an application of the PAR-1 antagonists to preparation of medicines for treating thrombotic diseases.

Alkoxy phenyl-substituted trans-cyclohexane amide compound and use thereof

The invention relates to the field of thrombotic disease related medicines. Specifically, the invention relates to a terminal alkoxy phenyl substituted trans-cyclohexane amide structured PAR-1 antagonist, a preparation method thereof and application of the antagonist in preparation of medicines for treating thrombotic diseases, wherein R is selected from C1-C3 alkyl and C3-C5 cycloalkyl.

5-ETHYL-IMIDAZO (5,1-F) (1,2,4,) TRIAZIN-4 (3H) -ONES AS PHOSPHODIESTERASE INHIBITORS

The invention relates to novel 5-ethyl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.

5-ETHYLIMIDAROTRIAZONES

The invention relates to novel 5-ethyl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.

Stereoelectronic Effects in Hydrogen-atom Transfer Reactions of Substituted Cyclohexyl Radicals

Thermolysis of the peroxyoxalates (1)-(7) and the diacyl peroxides (8)-(11) in cyclohexane at 100 deg C gives cycloalkenes and cycloalkanes by hydrogen-atom transfer reactions of the initially formed conformationally biased 4-t-butyl-, 4-t-butyl-cis,cis-2,6-dimethyl-, 4-t-butyl-cis,trans-2,6-dimethyl-, 4-t-butyl-cis-2-methyl-, 4-t-butyl-trans-2-methyl-, and 5-t-butyl-cis-2-methylcyclohexyl radicals (12)-(17).The composition of the product mixtures indicates that transfer of axial β-hydrogen atoms occurs more rapidly than does transfer of equatorial β-hydrogen atoms.These results support the hypothesis that homolytic fission of a C-H bond is favoured when it lies chlose to the plane of an adjacent semi-occupied orbital.