33603-87-1

Basic information

• Product Name: 2-Propenal, 3-chloro-3-phenyl-, (Z)-
• Synonyms: (2Z)-3-Chloro-3-phenyl-2-propenal;(Z)-3-chloro-3-phenylacrylaldehyde
• CAS NO: 33603-87-1
• Molecular Formula: C₉H₇ClO
• Molecular Weight: 166.6
• Mol File: 33603-87-1.mol
• Article Data: 38

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenal, 3-chloro-3-phenyl-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenal, 3-chloro-3-phenyl-, (Z)-(33603-87-1)
• EPA Substance Registry System: 2-Propenal, 3-chloro-3-phenyl-, (Z)-(33603-87-1)

Safety Data

• Hazardous Substances Data: 33603-87-1(Hazardous Substances Data)

Usage

Physical State

Colorless to yellow liquid

Odor

Pungent

Primary Use

Intermediate in pharmaceutical and agrochemical production

Other Uses

Synthesis of chiral compounds, cinnamoyl derivatives, and new chemical compounds

Safety

Corrosive substance, can cause irritation to skin, eyes, and respiratory tract

Important Properties

Versatile reagent in organic chemistry, building block in synthesis of chiral compounds

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 98-86-2 acetophenone 
• 39812-71-0 3-chloro-3-phenyl-1-prop-2-en-1-yliden-dimethyliminium perchlorate 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 536-74-3 phenylacetylene 
• 1131-80-2 (E)-3-(N,N-dimethylamino)-1-phenyl-2-propen-1-one 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 

Downstream Products

• 20851-48-3 2-Carboxy-5-chlor-5-phenyl-trans-pentadien-(2,4)-saeure 
• 5807-05-6 3-(morpholin-4-yl)-3-phenyl-2-propenal 
• 854673-32-8 C₉H₉ClO 
• 1151693-97-8 C₁₃H₁₆ClN 
• 1151693-98-9 C₁₅H₁₂ClN 
• 1207436-03-0 (E)-methyl 2-(4-fluorostyryl)-5-oxo-3-phenyl-2,5-dihydrofuran-2-carboxylate 
• 1207436-04-1 (E)-ethyl 2-(4-chlorostyryl)-5-oxo-3-phenyl-2,5-dihydrofuran-2-carboxylate 
• 1207436-05-2 ethyl 5-oxo-3-phenyl-2-((1E,3E)-4-phenylbuta-1,3-dienyl)-2,5-dihydrofuran-2-carboxylate 
• 1207436-15-4 diisopropyl 3-oxo-5-phenyl-1H-pyrazole-1,2(3H)-dicarboxylate 

Relevant articles and documents

Di-tert-Butyl Peroxide-Mediated Atom-Transfer Radical Addition of 2-Chlorodithiane to Aryl Alkynes under Mild Conditions

Atom transfer radical addition (ATRA) of 2-chlorodithiane onto aryl alkynes through the use of di-tert-butyl peroxide as an oxidant at room temperature directly affords a variety of synthetically valuable β-chloro-(Z)-vinyl dithianes in good yields with high regioselectivities and without the assistance of any transition metals. It provides an operationally simple pathway to access vinyl dithianes with controlled formation of a new C(sp2) - C bond and a C(sp2) - Cl bond.

MTA-Cooperative PRMT5 Inhibitors

The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

Regiodivergent Synthesis of Bis(4-oxycoumarin)-based Dioxabicycles: Exploration of [4 + 4] (Heterocyclo)reversion/addition and 1,5-Hydrogen Shift Photochromism

Two isomeric dioxabicyclic molecular skeletons were constructed by employing the concepts of divergent synthesis. A base-mediated and an acid-catalyzed pseudo-three-component reaction of two equivalents of 4-hydroxycoumarin and (Z)-3-chloro-3-phenylacryla