28521-49-5Relevant academic research and scientific papers
Continuous-Flow Synthesis of Phenothiazine Antipsychotics: A Feasibility Study
Movsisyan, Marine,De Coen, Laurens M.,Heugebaert, Thomas S. A.,Verlee, Arno,Roman, Bart I.,Stevens, Christian V.
, p. 1350 - 1354 (2019)
The continuous flow synthesis of a model phenothiazine antipsychotic is presented herein, using 3-chloropropionyl chloride as a central building block. The basic phenothiazine-derived scaffold is (atom)-efficiently and mildly synthesized with the aim to present continuous flow technology as a contributor to fast and efficient syntheses of challenging APIs, that are nowadays experiencing supply disruptions and global shortages.
