28525-08-8

Basic information

• Product Name: Acetic acid, diazo[(4-methylphenyl)sulfonyl]-, ethyl ester
• CAS NO: 28525-08-8
• Molecular Formula: C11H12N2O4S
• Molecular Weight: 268.293
• Mol File: 28525-08-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Acetic acid, diazo[(4-methylphenyl)sulfonyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, diazo[(4-methylphenyl)sulfonyl]-, ethyl ester(28525-08-8)
• EPA Substance Registry System: Acetic acid, diazo[(4-methylphenyl)sulfonyl]-, ethyl ester(28525-08-8)

Safety Data

• Hazardous Substances Data: 28525-08-8(Hazardous Substances Data)

Upstream product

• 3937-96-0 tosylacetic acid 
• 623-73-4 diazoacetic acid ethyl ester 
• 75-16-1 methylmagnesium bromide 
• 98-59-9 p-toluenesulfonyl chloride 
• 2850-19-3 (toluene-4-sulfonyl)-acetic acid ethyl ester 

Downstream Products

• 1436429-52-5 ethyl 2-(2-(1H-pyrazol-1-yl)phenyl)-2-tosylacetate 
• 1436430-23-7 ethyl 2-(3-methyl-2-(pyrimidin-2-yl)phenyl)-2-tosylacetate 

Relevant articles and documents

A method for synthesis of diazo methane compounds

The invention provides a synthetic method of a diazomethane compound. Diazotized sulfonyl-3,5,5-trimethyl-2-cyclohexenyl acetate is decarboxylated under the action of neutral alumina to obtain the high-purity and high-yield diazomethane compound. The synthetic method is carried out without using nitrosyl chloride which has the characteristics of high toxicity and easy blasting as a reaction raw material is environmentally-friendly and safe. The reaction yield is good, all the reactions are carried out with the temperature in a range from 0 to room temperature, and requirements on energy are low. The posttreatment process of the final product is simple, so expensive silica gel column chromatography separation is avoided. The reactant alumina has the effects of impurity separation and product purification, so the high-purity sulfonyl diazomethane derivative can be obtained through simple reduced pressure pumping filtration and concentration.

PREPARATION OF α-DIAZO-β-KETOSULFONES BY DIAZO-TRANSFER REACTION WITH AN IN SITU GENERATED AZIDINIUM SALT. A SAFE AND EFFICIENT PROCEDURE FOR THE DIAZO-TRANSFER REACTION IN NEUTRAL MEDIUM.

An efficinet and mild procedure is described for the preparation of α-diazo-β-ketosulfones using an azidinium salt generated in situ from relatively inexpensive and safe chemicals.The method is equally applicable to other CH2-acidic compounds.