192879-21-3Relevant academic research and scientific papers
A new type of plant activator: Synthesis of thieno[2,3-d][1,2,3]-thiadiazole-6-carboxylic acid derivatives via Hurd-Mori cyclization
Stanetty, Peter,Kremslehner, Manfred,Voellenkle, Horst
, p. 853 - 856 (2007/10/03)
We present a short and efficient synthesis of the title compounds starting with cheap and readily available methylenebutanedioic acid and thioacetic acid. The optimised sequence allows the large-scale preparation of this new type of plant activator in a few steps. ortho-Lithiation is used for the introduction of substituents into the 5-position. A modified reaction mechanism for the Hurd-Mori reaction is suggested to explain the unexpected aromatisation.
