28540-51-4

Basic information

• Product Name: 5-Chloro-1-benzothiophene-2-carbaldehyde
• Synonyms: 5-Chloro-1-benzothiophene-2-carbaldehyde;5-Chlorobenzo[b]thiophene-2-carbaldehyde;-Chloro-1-benzothiophene-2-carbaldehyde;5-Chloro-1-benzothiophene-2-carboxaldehyde
• CAS NO: 28540-51-4
• Molecular Formula: C9H5ClOS
• Molecular Weight: 197
• Mol File: 28540-51-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 135 °C(Solv: ethanol (64-17-5))
• Boiling Point: 338.8±22.0 °C(Predicted)
• Appearance: /
• Density: 1.439±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 5-Chloro-1-benzothiophene-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-1-benzothiophene-2-carbaldehyde(28540-51-4)
• EPA Substance Registry System: 5-Chloro-1-benzothiophene-2-carbaldehyde(28540-51-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 28540-51-4(Hazardous Substances Data)

Usage

Uses

5-Chloro-1-benzothiophene-2-carboxaldehyde possesses anti-viral activity against the PR8 strain of influenza A virus and IHD strain of vaccinia virus; Potential inhibitory agents for the treatment of prostate cancer.

Upstream product

• 123-09-1 4-chlorophenyl methyl sulfide 
• 68-12-2 N,N-dimethyl-formamide 
• 20532-33-6 5-chlorobenzothiophene 
• 50548-46-4 (4-chlorophenyl)(2,2-diethoxyethyl)sulfane 
• 106-54-7 p-Chlorothiophenol 

Downstream Products

• 99592-53-7 2-bromomethyl-5-chlorobenzo[b]thiophene 
• 13771-71-6 2-Hydroxymethyl-5-chlor-benzothiophen 

Relevant articles and documents

Catalytic Deprotonative α-Formylation of Heteroarenes by an Amide Base Generated in Situ from Tetramethylammonium Fluoride and Tris(trimethylsilyl)amine

Heteroarene formylations in DMF solution proceed in the presence of an amide base catalyst generated in situ from tetramethylammonium fluoride (TMAF) and tris(trimethylsilyl)amine (N(TMS)3). The reaction proceeds at room temperature and has an operationally simple procedure. Various heteroarenes, including benzothiophene, thiophene, benzothiazole, oxazole, and indole derivatives, can be formylated with high functional group tolerance.

N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and compounds I for use to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Fused ring compounds, process for producing the same and use thereof

To provide a novel compound of the formula: [wherein A1 ix a 5 or 6-membered ring which may be substituted by a group not containing a cyclic group, A2 is an aromatic ring which may be substituted, X is a divalent group, Y is a nitrogen atom or a methine group, Z is an ethenylene which may be substituted or ethynylene, R is a heterocyclic group which may be substituted, provided that 3,4-dihydro-6-[3-(1H-imidazol-1-yl)-1-propenyl]-2(1H)-quinolone and 2-[3-[5-ethyl-6-methyl-2-(benzyloxy)-3-pyridyl]-1-propenyl]benzoxazole are excluded.], or a salt thereof which has steroid C17,20-lyase inhibitory activity, and is useful for preventing and treating mammals suffering from, for example, primary cancer of malignant tumor, its metastasis and recurrence thereof.