28547-32-2

Basic information

• Product Name: 1-Propanone, 3-chloro-1-[4-(1-methylethyl)phenyl]-
• CAS NO: 28547-32-2
• Molecular Formula: C12H15ClO
• Molecular Weight: 210.704
• Mol File: 28547-32-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 3-chloro-1-[4-(1-methylethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 3-chloro-1-[4-(1-methylethyl)phenyl]-(28547-32-2)
• EPA Substance Registry System: 1-Propanone, 3-chloro-1-[4-(1-methylethyl)phenyl]-(28547-32-2)

Safety Data

• Hazardous Substances Data: 28547-32-2(Hazardous Substances Data)

Usage

Type

Synthetic opioid

Property

Powerful μ-opioid receptor agonist

Effects

Can cause severe respiratory depression, coma, and death

Legal status

Schedule I controlled substance in the United States (high potential for abuse and no accepted medical use)

Public health and safety risk

Significant risk due to its presence in street drugs

Monitoring and regulation

Efforts are ongoing to monitor and regulate its production and distribution.

Upstream product

• 98-82-8 Isopropylbenzene 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 5120-34-3 5-isopropyl-1-indanone 
• 134563-03-4 3-[3-(4-Isopropyl-phenyl)-3-oxo-propyl]-3H-quinazolin-4-one 
• 95939-44-9 5-Isopropyl-2-(4-dimethylamino-benzyliden)-indanon-⁽¹⁾ 

Relevant articles and documents

Synthesis and Evaluation of 2-Azetidinone and 1H-Pyrrole-2,5-dione Derivatives as Cholesterol Absorption Inhibitors for Reducing Inflammation Response and Oxidative Stress

Excess lipid accumulation can initiate the development and progression of atherosclerotic lesions, thus eventually leading to cardiovascular disease. Lipid-lowering medication therapy is one of the cornerstones of cardiovascular disease therapy. On the basis of the cholesterol absorption inhibitor ezetimibe, we successfully synthesized seven 2-azetidinone derivatives and eighteen 1H-pyrrole-2,5-dione derivatives. Most of the new compounds significantly inhibited cholesterol uptake in vitro. In addition, one of the most active inhibitors, 3-(4-fluorophenyl)-1-[(3S)-3-hydroxy-3-(4-hydroxyphenyl)propyl]-4-(4-hydroxyphenyl)-1H-pyrrole-2,5-dione (14q), showed no cytotoxicity in L02 and HEK293T cell lines. Further evaluation indicated that 14q inhibited considerably the amount of TNF-α, ROS, MDA, and LDH in vitro. Therefore, 14q might be a novel cholesterol absorption inhibitor.