28557-24-6

Usage

InChI:InChI=1/C11H15N5O3/c1-13-8-7(9(18)14(2)11(13)19)16-4-3-15(5-6-17)10(16)12-8/h17H,3-6H2,1-2H3

Upstream product

• 49687-13-0 dimethyl-1,3 dioxo-2,4 dihydro-6,7 (chloro-2 ethyl)-8 1H,3H,8H imidazo<2,1-f>purine 
• 31580-04-8 (chloro-2 ethyl)-7 bromo-8 theophylline 
• 141-43-5 ethanolamine 
• 58431-80-4 8-bromo-7-(2-bromoethyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione 
• 10381-75-6 8-bromotheophylline 
• 49687-11-8 8-bis(2-chloroethyl)aminotheophylline 

Downstream Products

• 49687-41-4 8-[2-(4-phenyl-1-piperazinyl)-ethyl]-1,3,6,7-tetrahydro-(8H)-imidazo[2,1-f]theophylline 

Relevant academic research and scientific papers

Synthesis and CNS activity of tricyclic theophylline derivatives. 8- substituted imidazo[2,1-f]theophyllines

Based on previously described results of pharmacological in vitro and in vivo tests of some series of pyrimido- and diazepino-[2,1-f]theophylline derivatives, N8-unsubstituted, N8-benzyl and N8-arylpiperazino-alkyl derivatives of imidazo[2,1-f]theophyllines were synthesized and tested for their CNS activity. It has been shown that tricyclic [2,1-f]theophyllines possess sedative and analgesic activity. N8-Phenylpiperazinopropyl-1,3,6,7- tetrahydro-(8H)-imidazo[2,1-f]theophylline 6 showed significant anti- serotonin and long-lasting hypothermic effects. N8-Benzyl-1,3,6,8- tetrahydroimidazo-7-on[2,1-f]theophylline 8 possess anticonvulsant properties.