49687-41-4

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 261156-66-5 8-(β-bromoethyl)-1,3,6,7-tetrahydro-(8H)-imidazo[2,1-f]theophylline 
• 58431-80-4 8-bromo-7-(2-bromoethyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione 
• 28557-24-6 dimethyl-1,3 dioxo-2,4 dihydro-6,7 (hydroxy-2 ethyl)-8 1H,3H,8H imidazo<2,1-f>purine 

Relevant academic research and scientific papers

Synthesis and CNS activity of tricyclic theophylline derivatives. 8- substituted imidazo[2,1-f]theophyllines

Based on previously described results of pharmacological in vitro and in vivo tests of some series of pyrimido- and diazepino-[2,1-f]theophylline derivatives, N8-unsubstituted, N8-benzyl and N8-arylpiperazino-alkyl derivatives of imidazo[2,1-f]theophyllines were synthesized and tested for their CNS activity. It has been shown that tricyclic [2,1-f]theophyllines possess sedative and analgesic activity. N8-Phenylpiperazinopropyl-1,3,6,7- tetrahydro-(8H)-imidazo[2,1-f]theophylline 6 showed significant anti- serotonin and long-lasting hypothermic effects. N8-Benzyl-1,3,6,8- tetrahydroimidazo-7-on[2,1-f]theophylline 8 possess anticonvulsant properties.