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28566-10-1

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28566-10-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 28566-10-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,5,6 and 6 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 28566-10:
(7*2)+(6*8)+(5*5)+(4*6)+(3*6)+(2*1)+(1*0)=131
131 % 10 = 1
So 28566-10-1 is a valid CAS Registry Number.

28566-10-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-methyl-4-oxo-3-phenyl-1H-quinolin-2-olate

1.2 Other means of identification

Product number -
Other names 4-Hydroxy-6-methyl-3-phenyl-2(1H)-chinolon

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:28566-10-1 SDS

28566-10-1Relevant articles and documents

Design, synthesis and antitubercular potency of 4-hydroxyquinolin-2(1H)-ones

de Macedo, Maíra Bidart,Kimmel, Roman,Urankar, Damijana,Gazvoda, Martin,Peixoto, Antonio,Cools, Freya,Torfs, Eveline,Verschaeve, Luc,Lima, Emerson Silva,Ly?ka, Antonín,Mili?evi?, David,Klásek, Antonín,Cos, Paul,Kafka, Stanislav,Ko?mrlj, Janez,Cappoen, Davie

, p. 491 - 500 (2017/07/10)

In this study, a 50-membered library of substituted 4-hydroxyquinolin-2(1H)-ones and two closely related analogues was designed, scored in-silico for drug likeness and subsequently synthesized. Thirteen derivatives, all sharing a common 3-phenyl substituent showed minimal inhibitory concentrations against Mycobacterium tuberculosis H37Ra below 10 μM and against Mycobacterium bovis AN5A below 15 μM but were inactive against faster growing mycobacterial species. None of these selected derivatives showed significant acute toxicity against MRC-5 cells or early signs of genotoxicity in the Vitotox assay at the active concentration range. The structure activity study relation provided some insight in the further favourable substitution pattern at the 4-hydroxyquinolin-2(1H)-one scaffold and finally 6-fluoro-4-hydroxy-3-phenylquinolin-2(1H)-one (38) was selected as the most promising member of the library with a MIC of 3.2 μM and a CC50 against MRC-5 of 67.4 μM.

Efficient preparation of 4-hydroxyquinolin-2(1 H)-one derivatives with silver-catalyzed carbon dioxide incorporation and intramolecular rearrangement

Ishida, Tomonobu,Kikuchi, Satoshi,Yamada, Tohru

, p. 3710 - 3713 (2013/08/23)

Although 4-hydroxyquinolin-2(1H)-one derivatives have attracted much attention due to their biological benefits, conventional reactions under harsh heat conditions must be employed to provide these key compounds. In the presence of a catalytic amount of s

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