28614-56-4

Upstream product

• 676-85-7 methylsulphinyl chloride 
• 70-55-3 toluene-4-sulfonamide 
• 132792-39-3 N-(p-tolylsulfonyl)methanesulfinamide 
• 7080-50-4 chloramine T trihydrate 
• 473-34-7 N,N-dichloro-p-toluenesulfonamide 
• 127-65-1 chloroamine-T 

Downstream Products

• 14653-91-9 (N-methanesulfone)-N-(4-methylbenzene)sulfonimide 
• 69726-83-6 N-(p-Tolylsulfonyl)-methansulfonimidamid 
• 69726-78-9 N-(p-Tolylsulfonyl)chlormethansulfinamid 
• 69726-84-7 N-[(dimethylamino)methyloxido-λ⁶-sulfanylidene]-4-methylbenzenesulfonamide 
• 93938-04-6 S-methyl-S-morpholino-N-<(4-methylphenyl)sulfonyl>sulfoximine 
• 118657-16-2 N,N-dibutyl-N'-<(4-methylphenyl)sulfonyl>methanesulfonimidamide 
• 33872-04-7 N-(p-Tolylsulfonyl)-chlormethansulfonimidoylchlorid 
• 69727-03-3 N-(p-Tolylsulfonyl)chlormethansulfonamid 
• 69726-85-8 N-(p-Tolylsulfonyl)-trichlormethansulfinamid 
• 1264737-55-4 N-(4-methylbenzenesulfonyl) methyl sulfonimidoyl fluoride 
• 1548337-21-8 C₂₉H₃₅F₂N₅O₆S₂ 
• 1548337-02-5 C₁₃H₁₆N₄O₃S₂ 
• 1548337-03-6 C₁₃H₁₆N₄O₃S₂*C₂HF₃O₂ 
• 1548336-94-2 C₁₈H₂₄N₄O₅S₂ 

Relevant academic research and scientific papers

FUNGICIDAL OXADIAZOLES

Disclosed are compounds of Formula 1, including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein R1, R2, A, L and J are as defined in the disclosure. Also disclosed are compositions containing the comp

INDOLEAMINE 2,3-DIOXYGENASE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION

The present invention relates to an indoleamine 2,3-dioxygenase inhibitor having the structure of formula (I), a preparation method therefor, and an application. The IDO inhibitor is an N′-hydroxyl-N-phenylformamidine derivative, which has a high inhibito

NOVEL SUBSTITUTED SULFOXIMINE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS

Compounds of Formula I, or a pharmaceutically acceptable salt, solvate or hydrate thereof: (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

TREATING DIABETES WITH DIPEPTIDYL PEPTIDASE-IV INHIBITORS

The present invention is directed to novel substituted dihydropyrrolopyrazoles of structural Formula I which are inhibitors of the dipeptidyl peptidase-N enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase IV enzyme is involved.

S-IMINO-S-OXO IMINOTHIADIAZINE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE

In its many embodiments, the present invention provides provides certain S-imino-S-oxo iminothiadiazine compounds, including compounds Formula (I): or a tautomers and/or stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomeros and said stereoisomers, wherein RN, R1, R2, R3, R4, ring A, RA, m, L1, and RL are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and may be useful for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.

Synthesis of CF3-substituted sulfoximines from sulfonimidoyl fluorides

N-Protected trifluoromethyl-substituted sulfoximines have been prepared by treatment of sulfonimidoyl fluorides with a combination of the Ruppert-Prakash reagent (TMSCF3) and tetrabutyl ammonium fluoride (TBAF). The starting materials were accessed following two synthetic routes, and for each reaction sequence the substrate scope was evaluated. Accordingly, a wide variety of aryl-substituted products were obtained in moderate to good yield.

Reaction of sulfonimidamide Anions with Electrophiles

The reaction of alkylsulfonimidamides with bases gave corresponding carboanions, which were allowed to react with carbonyl compounds to give (2-hydroxyalkyl)sulfonimidamides in good yields.When benzoic anhydride or chlorotrimethylsilane was treated with these anions, corresponding phenacylsulfonimidamides or (trimethylsilyl)methylsulfonimidamides were obtained.On the other hand, the reaction of methyl N-p-tosylsulfonimidmorpholide anion with carbonyl compounds afforded epoxides or oxetanes in good yields.