286371-45-7Relevant academic research and scientific papers
URACIL DERIVATIVES AS AXL AND C-MET KINASE INHIBITORS
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Page/Page column 120; 127, (2013/06/05)
The present invention provides compounds of Formula I, or pharmaceutically acceptable salt forms thereof, wherein Ra, Rb, Rc, Rd, D, W, R1a, R1b, R1c,Y, R3, X, E and G are as defined herein, methods of treatment and uses thereof.
Orally active anti-proliferation agents: Novel diphenylamine derivatives as FGF-R2 autophosphorylation inhibitors
Shimizu, Toshiyuki,Fujiwara, Yasunari,Osawa, Tatsushi,Sakai, Teruyuki,Kubo, Kinya,Kubo, Kazuo,Nishitoba, Tsuyoshi,Kimura, Kaname,Senga, Terufumi,Murooka, Hideko,Iwai, Akemi,Fukushima, Kayoko,Yoshino, Tetsuya,Miwa, Atsushi
, p. 875 - 879 (2007/10/03)
(6,7-Disubstituted-quinolin-4-yloxy-phenyl)(4-substituted-phenyl)amine derivatives were synthesized and evaluated by a cellular autophosphorylation assay for FGF-R2 in the human scirrhous gastric carcinoma cell line, OCUM-2MD3. We also performed metabolic
QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES
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, (2008/06/13)
An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: wherein X and Z each independently represent CH or N; R1 to R3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R4 represents H; R5 to R8 represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R5 to R8 do not simultaneously represent H; R9 and R10 represent H, alkyl, or alkylcarbonyl; and R11 represents alkyl, alkenyl, alkynyl, or aralkyl.
