286374-31-0

Upstream product

• 222835-55-4 N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)-6-(9-fluorenylmethyloxy-carbonylamino)-4-benzyloxy-1-iodo-2-naphthylamine 
• 222835-56-5 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-chloromethyl-7-(9-fluorenylmethyloxy-carbonylamino)-1,2-dihydro-3H-benz[e]indole 

Downstream Products

• 261763-48-8 C₅₅H₅₈Cl₂N₄O₈ 
• 261763-49-9 C₅₆H₆₀Cl₂N₄O₈ 
• 261763-51-3 C₅₈H₆₄Cl₂N₄O₈ 
• 261763-56-8 7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester 
• 261763-69-3 7-[5-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-5-oxo-pentanoylamino]-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indole-3-carboxylic acid tert-butyl ester 
• 261763-70-6 7-[6-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-6-oxo-hexanoylamino]-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indole-3-carboxylic acid tert-butyl ester 
• 261763-71-7 7-[7-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-7-oxo-heptanoylamino]-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indole-3-carboxylic acid tert-butyl ester 
• 261763-72-8 7-[8-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-8-oxo-octanoylamino]-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indole-3-carboxylic acid tert-butyl ester 
• 439599-60-7 5-benzyloxy-7-(3-carboxypropionylamino)-1-chloromethyl-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester 
• 261763-65-9 5-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-5-oxo-pentanoic acid 
• 261763-66-0 6-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-6-oxo-hexanoic acid 
• 261763-67-1 7-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-7-oxo-heptanoic acid 
• 261763-68-2 8-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-8-oxo-octanoic acid 
• 261763-57-9 N-{3-[5-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-5-oxo-pentanoyl]-5-benzyloxy-1-chloromethyl-2,3-dihydro-1H-benzo[e]indol-7-yl}-acetamide 

Relevant academic research and scientific papers

Design, synthesis and cytotoxicity evaluation of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI) dimers

Three types of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI) dimers were designed, synthesized and evaluated in vitro by NCI against nine types of cancer cells. Biological results showed that the antitumor activities of these seco-CBI dimers were strongly related to the position and length of the linker and generally with potency increasing in the order of C7-C7 dimers (22i-iv)50 values50 values0.01μM against all the cell lines and showed the highest overall potency of the agents examined (GMG=0.0120μM). Copyright (C) 2000 Elsevier Science Ltd.

Synthesis of an unsymmetrical bis-lexitropsin-1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI) conjugate

A practical synthesis of a novel bis-functionalized precursor of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e] (CBI) is described; the first unsymmetrical bis-lexitropsin-CBI precursor conjugate was thereby synthesized.