286430-88-4

Upstream product

• 55896-93-0 ethyl 2-(chlorosulfonyl)acetate 
• 220220-32-6 tert-butyl 4-(4-{[(7-cyano-2-naphthyl)methyl]amino}phenyl)-1,4-diazepane-1-carboxylate 
• 350-46-9 4-Fluoronitrobenzene 
• 220220-23-5 tert-butyl 4-(4-nitrophenyl)-1,4-diazepane-1-carboxylate 
• 441313-14-0 4-(4-aminophenyl)-[1,4]-diazepane-1-carboxylic acid tert-butyl ester 

Downstream Products

• 714249-35-1 ethyl ({({7-[amino(imino)methyl]-2-naphthyl}methyl)[4-(4-butyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate 
• 220220-41-7 ethyl ({({7-[amino(imino)methyl]-2-naphthyl}methyl)[4-(4-ethanimidoyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate 
• 714249-33-9 ethyl ({[4-(4-benzyl-1,4-diazepan-1-yl)phenyl][(7-cyano-2-naphthyl)methyl]amino}sulfonyl)acetate 
• 714249-32-8 ethyl ({[4-(4-butyl-1,4-diazepan-1-yl)phenyl][(7-cyano-2-naphthyl)methyl]amino}sulfonyl)acetate 
• 714249-34-0 ethyl ({({7-[amino(imino)methyl]-2-naphthyl}methyl)[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate 
• 714249-31-7 ethyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate 

Relevant academic research and scientific papers

Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity

Factor Xa (fXa) is a serine protease involved in the coagulation cascade, which has received great interest as a potential target for the development of new antithrombotic drugs. Herein we report a novel series of fXa inhibitors in which the 1,4-diazepane moiety was designed to interact with the S4 aryl-binding domain of the fXa active site. Compound 13 (YM-96765) showed potent fXa inhibitory activity (IC50=6.8nM) and effective antithrombotic activity without prolonging bleeding time.