286440-95-7

Usage

Uses

Used in Pharmaceutical Synthesis:
1-((5-bromopentyloxy)methyl)-4-methoxybenzene is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs and pharmaceutical products. Its unique structure allows for the creation of a wide range of compounds with different therapeutic properties.
Used in Research Chemicals:
In the field of research, 1-((5-bromopentyloxy)methyl)-4-methoxybenzene serves as a valuable research chemical. It can be used to study the properties and behavior of similar compounds, as well as to develop new methods and techniques in organic synthesis and medicinal chemistry.
Used in Organic Synthesis:
1-((5-bromopentyloxy)methyl)-4-methoxybenzene is used as a reagent in organic synthesis, where it can be employed to create a variety of new compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-((5-bromopentyloxy)methyl)-4-methoxybenzene is used as a starting material for the development of new drugs. Its unique structure and functional groups make it an attractive candidate for the design and synthesis of novel therapeutic agents.

Upstream product

• 111-24-0 1,5-dibromo-pentane 
• 824-94-2 p-methoxybenzyl chloride 
• 111-29-5 1 ,5-pentanediol 
• 131375-63-8 5-(4-methoxybenzyloxy)-1-pentanol 

Downstream Products

• 871095-00-0 tert-butyl((1R,2R,3aS,6aS)-5-(5-(4-methoxybenzyloxy)pentyl)-1-((E)-4-m-tolylbut-1-enyl)-1,2,3,3a,6,6a-hexahydropentalen-2-yloxy)dimethylsilane 
• 871095-02-2 5-((3aS,5R,6R,6aS)-5-(tert-butyldimethylsilyloxy)-6-((E)-4-m-tolylbut-1-enyl)-1,3a,4,5,6,6a-hexahydropentalen-2-yl)pentanoic acid 
• 871095-01-1 5-((3aS,5R,6R,6aS)-5-(tert-butyldimethylsilyloxy)-6-((E)-4-m-tolylbut-1-enyl)-1,3a,4,5,6,6a-hexahydropentalen-2-yl)pentan-1-ol 
• 871095-05-5 ((1S,2R,3aS,6aS)-2-(tert-butyldimethylsilyloxy)-5-(5-(4-methoxybenzyloxy)pentyl)-1,2,3,3a,6,6a-hexahydropentalen-1-yl)methanol 
• 871095-07-7 5-((3aS,5R,6R,6aS)-5-(tert-butyldimethylsilyloxy)-6-((E)-4-m-tolylbut-1-enyl)-1,3a,4,5,6,6a-hexahydropentalen-2-yl)pentanal 
• 871094-94-9 (1R,2R,3aS,6aS)-2-(tert-butyldimethylsilyloxy)-5-(5-(4-methoxybenzyloxy)pentyl)-1,2,3,3a,6,6a-hexahydropentalene-1-carbaldehyde 
• 871094-98-3 tert-butyl((1S,2R,3aS,6aS)-5-(5-(4-methoxybenzyloxy)pentyl)-1-(trityloxymethyl)-1,2,3,3a,6,6a-hexahydropentalen-2-yloxy)dimethylsilane 

Relevant academic research and scientific papers

METHOD FOR PRODUCING PROSTAGLANDIN DERIVATIVE, PROSTAGLANDIN DERIVATIVE, INTERMEDIATE COMPOUND THEREFOR AND METHOD FOR PRODUCING THE SAME

PROBLEM TO BE SOLVED: To provide a method for producing a prostaglandin derivative, the prostaglandin derivative and an intermediate compound therefor, especially a method for producing a δ-12-prostaglandin J2 derivative using a new method for chemical synthesis through the intermediate compound. SOLUTION: The method for production is a method for producing the prostaglandin derivative using (1R,3R)-4-cyclopentene-1,3-diol 3-acetate (carboxylate) as a starting material. The method is composed of (A) an α-side chain introduction step of providing a malonic acid ester addition compound at the 3-position of the (1R,3R)-4-cyclopentene-1,3-diol, (B) an α-side chain extension step of affording a (1R,3R)-4-cyclopenten-1-one compound having the α-side chain of the prostaglandin derivative at the 3-position and (C) a prostaglandin derivative synthesizing step of conversion into the prostaglandin derivative.

Access to isocarbacyclin derivatives via substrate-controlled enolate formation: Total synthesis of 15-deoxy-16-(m-tolyl)-17,18,19,20- tetranorisocarbacyclin

(Chemical Equation Presented) We describe a convergent and flexible synthesis of 15-deoxy-16-(m-tolyl)-17,18,19,20-tetranorisocarbacyclin (15-deoxy-TIC), a simple isocarbacyclin derivative. The synthesis takes advantage of two key step reactions: a regioselective deprotonation of the described ketone under substrate control which is then trapped, as the enol triflate, to generate the C6-C9α endocyclic double bond, followed by an sp2-sp3 Pd-catalyzed cross-coupling reaction (C5-C6) with a suitable primary alkyl Grignard reagent. Introduction of the C13-C14 (E)-double bond in the ω-side chain is performed by the Julia-Kocienski olefination.