286441-92-7

Upstream product

• 2835-98-5 2-Hydroxy-4-methylanilin 
• 98-59-9 p-toluenesulfonyl chloride 
• 286441-91-6 toluene-4-sulfonic acid 2-amino-5-methyl-phenyl ester 

Downstream Products

• 286441-93-8 toluene-4-sulfonic acid 2-amino-3',5'-dimethoxy-5-methyl-biphenyl-3-yl ester 
• 286441-94-9 toluene-4-sulfonic acid 2-amino-2'-bromo-3',5'-dimethoxy-5-methyl-biphenyl-3-yl ester 
• 286441-95-0 toluene-4-sulfonic acid 6,8-dimethoxy-3-methyl-9H-carbazole-1-yl ester 

Relevant academic research and scientific papers

Synthesis of optically pure Clausenamine-A and its demethoxylated analogs

The first total synthesis of Clausenamine-A (3) was developed involving the Suzuki cross-coupling and oxidative coupling reaction. The synthesis of its demethoxylated analogs 1 and 2 were also reported. Resolution of (+)-1, (+)-2, (+)-3 and (-)-1, (-)-2, (-)-3 were performed via their corresponding camphorsulfonates of the racemates. The absolute configurations of (+)-1, (+)-2, (+)-3 and (-)-1, (-)-2, (-)-3 were assigned as (aR) and (aS), respectively, by X-ray analysis and their CD spectrum. The primarily cytotoxic activities of these biscarbazoles against Plasmodium falciparum were briefly described. (C) 2000 Elsevier Science Ltd.

The first synthesis of clausenamine-A and cytotoxic activities of three biscarbazole analogues against cancer cells

Clausemine-A (3), isolated from the stem and root bark of Clausena excavata, was synthesized using Suzuki cross-coupling and Oxidative coupling as the key step. Compound 3, and the other two structurally related biscarbazoles 1 and 2, showed potent cytotoxic activities a variety of human cancer cell lines in vitro. (C) 2000 Elsevier Science Ltd. All rights reserved.