286441-91-6

Basic information

• Product Name: toluene-4-sulfonic acid 2-amino-5-methyl-phenyl ester
• Synonyms: toluene-4-sulfonic acid 2-amino-5-methyl-phenyl ester
• CAS NO: 286441-91-6
• Molecular Weight: 277.344
• Mol File: 286441-91-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: toluene-4-sulfonic acid 2-amino-5-methyl-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: toluene-4-sulfonic acid 2-amino-5-methyl-phenyl ester(286441-91-6)
• EPA Substance Registry System: toluene-4-sulfonic acid 2-amino-5-methyl-phenyl ester(286441-91-6)

Safety Data

• Hazardous Substances Data: 286441-91-6(Hazardous Substances Data)

Upstream product

• 95-84-1 3-amino-4-hydroxytoluene 
• 98-59-9 p-toluenesulfonyl chloride 
• 2835-98-5 2-Hydroxy-4-methylanilin 

Downstream Products

• 286441-94-9 toluene-4-sulfonic acid 2-amino-2'-bromo-3',5'-dimethoxy-5-methyl-biphenyl-3-yl ester 
• 286441-95-0 toluene-4-sulfonic acid 6,8-dimethoxy-3-methyl-9H-carbazole-1-yl ester 
• 286441-93-8 toluene-4-sulfonic acid 2-amino-3',5'-dimethoxy-5-methyl-biphenyl-3-yl ester 
• 863301-19-3 N-[2-(trimethylsilyl)ethoxymethyl]-3-methyl-6-nitro-1-(4-toluenesulfonyloxy)carbazole 
• 863301-18-2 3-methyl-6-nitro-1-(4-toluenesulfonyloxy)carbazole 
• 863301-14-8 2-amino-2'-bromo-5-methyl-3-(4-toluenesulfonyloxy)-1,1'-biphenyl 
• 863301-15-9 2,2'-dibromo-5-methyl-3-(4-toluenesulfonyloxy)-1,1'-biphenyl 
• 863301-13-7 4-toluenesulfonic acid 2-amino-3-iodo-5-methylphenyl ester 
• 863301-17-1 4-toluenesulfonic acid 5-methyl-2-[(4-nitrophenyl)amino]phenyl ester 
• 286441-92-7 toluene-4-sulfonic acid 2-amino-3-bromo-5-methylphenyl ester 

Relevant articles and documents

The first synthesis of clausenamine-A and cytotoxic activities of three biscarbazole analogues against cancer cells

Clausemine-A (3), isolated from the stem and root bark of Clausena excavata, was synthesized using Suzuki cross-coupling and Oxidative coupling as the key step. Compound 3, and the other two structurally related biscarbazoles 1 and 2, showed potent cytotoxic activities a variety of human cancer cell lines in vitro. (C) 2000 Elsevier Science Ltd. All rights reserved.

ANTI-TRICHOPHYTIC ADHESIVE PATCH

According to the present invention, a patch for nail and/or skin having antifungal activity against dermatophytes, and having higher nail permeability can be provided. The patch for nail and/or skin for prevention or treatment of dermatophytosis comprises in a pressure sensitive adhesive layer a compound represented by the formula: wherein R1 represents a hydrogen atom, C1-6 alkyl, or trifluoromethyl; R2 represents a hydrogen atom, C1-6 alkyl, halogen, -COO(C1-6 alkyl), or (CH2)1-3COOR (R represents a hydrogen atom or C1-6 alkyl); R3 represents a hydrogen atom, C1-6 alkyl, amino, trifluoromethyl, or OR (R represents a hydrogen atom or C1-6 alkyl); R4 represents a hydroxyl group; R5 represents a hydrogen atom, C1-6 alkyl, a hydroxyl group, or halogen; R6 represents a hydrogen atom, C1-6 alkyl, trifluoromethyl, halogen, amino, -NRaRb, nitro, hydroxy-C1-6 alkyl, -CONRaRb, -COO(C1-6 alkyl), -COOH, -(CH2)1-3COOR, or ORa (R represents a hydrogen atom or C1-6 alkyl, Ra and Rb may be the same or different from each other, and each represent a hydrogen atom, C1-6 alkyl, or C1-6 acyl); R7 represents a hydrogen atom, C1-6 alkyl, -OR (R represents a hydrogen atom or C1-6 alkyl), or halogen; and R8 represents a hydrogen atom, C1-6 alkyl, a hydroxyl group, amino, or nitro, or a salt thereof.

TOPICAL LIQUID AGENT FOR THE TREATMENT OF DERMATOPHYTOSIS

A topical liquid agent for a nail and/or skin for prevention or treatment of dermatophytosis comprises a film-forming agent and a compound represented by the formula: wherein R1 represents hydrogen, C1-6 alkyl, or trifluoromethyl, R2 represents hydrogen, C1-6 alkyl, halogen, —COO(C1-6 alkyl), or (CH2)1-3COOR where R represents hydrogen or C1-6 alkyl, R3 represents hydrogen, C1-6 alkyl, amino, trifluoromethyl, or OR where R represents hydrogen or C1-6 alkyl, R4 represents hydroxyl, R5 represents hydrogen, C1-6 alkyl, hydroxyl, or halogen, R6 represents hydrogen, C1-6 alkyl, trifluoromethyl, halogen, amino, —NRaRb, nitro, hydroxy-C1-6 alkyl, —CONRaRb, —COO(C1-6 alkyl), —COOH, —(CH2)1-3COOR, or ORa where R represents hydrogen or C1-6 alkyl, Ra and Rb each represent hydrogen, C1-6 alkyl, or C1-6 acyl, R7 represents hydrogen, C1-6 alkyl, —OR where R represents hydrogen or C1-6 alkyl, or halogen, R8 represents hydrogen, C1-6 alkyl, hydroxyl, amino, or nitro, or a salt thereof.