286462-34-8

Upstream product

• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 132566-28-0 ethyl 3-(4-methoxyphenyl)-4-phenyl-4-oxobutanoate 
• 24845-40-7 2-(4-methoxyphenyl)acetophenone 
• 104-01-8 4-Methoxyphenylacetic acid 

Downstream Products

• 433330-64-4 5-(4-methoxyphenyl)-6-phenylpyridazin-3(2H)-one 
• 433330-65-5 6-chloro-4-(4-methoxy-phenyl)-3-phenyl-pyridazine 
• 433330-63-3 5-(4-methoxy-phenyl)-6-phenyl-4,5-dihydro-2H-pyridazin-3-one 

Relevant academic research and scientific papers

Mono- and di-substituted 5,6-diphenyl-3-alkylaminopyridazines active as ACAT inhibitors

A series of mono- or di-para-substituted 5,6-diphenyl-3-alkylaminopyridazines were synthesized and their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. The compound which combines a chlorine atom on the 6-phenyl ring and a n-hexylamino chain showed a significant enhancement of activity with respect to the unsubstituted derivative. Attempts to correlate the activity of the compounds to their structural features, also through theoretical calculations, are reported.