433330-65-5

Upstream product

• 5720-07-0 4-methoxyphenylboronic acid 
• 433935-99-0 5-bromo-6-chloro-3-phenylpyridazine 
• 433330-64-4 5-(4-methoxyphenyl)-6-phenylpyridazin-3(2H)-one 
• 90766-97-5 5-bromo-6-phenylpyridazin-3(2H)-one 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 433330-63-3 5-(4-methoxy-phenyl)-6-phenyl-4,5-dihydro-2H-pyridazin-3-one 
• 286462-34-8 3-(4-methoxy-phenyl)-4-oxo-4-phenyl-butyric acid 
• 132566-28-0 ethyl 3-(4-methoxyphenyl)-4-phenyl-4-oxobutanoate 
• 24845-40-7 2-(4-methoxyphenyl)acetophenone 
• 104-01-8 4-Methoxyphenylacetic acid 

Downstream Products

• 433330-64-4 5-(4-methoxyphenyl)-6-phenylpyridazin-3(2H)-one 

Relevant academic research and scientific papers

Mono- and di-substituted 5,6-diphenyl-3-alkylaminopyridazines active as ACAT inhibitors

A series of mono- or di-para-substituted 5,6-diphenyl-3-alkylaminopyridazines were synthesized and their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. The compound which combines a chlorine atom on the 6-phenyl ring and a n-hexylamino chain showed a significant enhancement of activity with respect to the unsubstituted derivative. Attempts to correlate the activity of the compounds to their structural features, also through theoretical calculations, are reported.

Pyridazines. Part 26: Efficient and regioselective Pd-catalysed arylation of 4-bromo-6-chloro-3-phenylpyridazine

The regioselective arylation at position 4 of 4-bromo-6-chloro-3-phenylpyridazine has been performed using a Suzuki cross-coupling reaction. This route allows access to a wide-ranging series of pharmacologically useful pyridazine derivatives and confirms