28660-35-7

Upstream product

• 102-96-5 (2-nitroethenyl)benzene 
• 49747-42-4 N-(2-phenyl-1-vinyl)benzamide 
• 5153-67-3 nitrostyrene 
• 37909-65-2 diethyl (2-nitro-1-phenylethyl)phosphonate 
• 126435-44-7 3-(Diethoxy-phosphoryl)-3-phenyl-propionic acid methyl ester 
• 28660-31-3 (2-Carbamoyl-1-phenyl-ethyl)-phosphonic acid diethyl ester 
• 37909-71-0 (2-Amino-1-phenyl-ethyl)-phosphonic acid diethyl ester 

Downstream Products

• 37909-71-0 (2-Amino-1-phenyl-ethyl)-phosphonic acid diethyl ester 
• 117196-72-2 (2-Formylamino-1-phenyl-ethyl)-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

A Reagent-Controlled Phospha-Michael Addition Reaction of Nitroalkenes with Bifunctional N-Heterocyclic Phosphine (NHP)-Thioureas

Bifunctional N-heterocyclic phosphine (NHP)-thioureas have been successfully applied for phospha-Michael addition reaction of nitroalkenes to afford diversely substituted β-nitrodiazaphosphonates. This transformation takes place at room temperature under catalyst-free conditions and exhibits broad functional group tolerance. The key to success in catalyst, additive-free reaction conditions is the suitable hydrogen-bond activation of the nitro group by a Br?nsted acid (thiourea), which artfully combined with the highly nucleophilic NHP motif for a synergetic effect. Importantly, this transformation enables a two-step synthesis of pharmaceutically, biologically significant β-amino phosphonic acids.

BETA-PHOSPHONYL-ENAMINE DERIVATIVE AND PREPARATION METHOD THEREFOR

The present invention discloses the preparation method of β-phosphonyl-enamine derivative. The preparation method comprising the following steps: dissolving the enamine derivative, organic phosphine compound, manganese acetate and potassium carbonate in the solvent, reacting at room temperature to obtain the β-phosphonyl-enamine derivative. The enamine derivative was as the starting material, and the raw materials are easy to obtain and a great many varieties. The various forms of the products obtained therein can be directly applied and can be used in further reactions. The reaction conditions are mild, the reaction speed is high, the reaction operation and the post-treatment process are simple, the production is convenient, and the method is suitable for large-scale production.

BETA-AMINO PHOSPHONIC ACID DERIVATIVE AND PREPARATION METHOD THEREFOR

A method for preparing a β-amino phosphonic acid derivative includes: dissolving N-(arylvinyl)benzamide, dialkyl phosphite, manganese acetate, and potassium carbonate in a solvent and reacting at room temperature to obtain (2-benzamido-1-arylvinyl)dialkyl-phosphonate derivative; and hydrolyzing (2-benzamido-1-arylethyl) dialkylphosphonate derivative to obtain β-amino phosphonic acid derivative. The N-(arylvinyl) benzamide derivative is used as starting material. The raw materials are easy to obtain and are of many different types. A method of preparing β-aminophosphonic acid derivative includes: dissolving N-(arylvinyl)benzamide, dialkyl phosphite, manganese acetate and potassium carbonate in a solvent, reacting at room temperature to obtain (2-benzamide-1-arylvinyl) dialkyl phosphonate derivative, and then reducing and hydrolyzing the compound to obtain β-aminophosphonic acid derivative. The method of the invention has the advantages of short synthesis route, mild reaction conditions, simple reaction operation and post-treatment process, good yield, and is suitable for large-scale production.

Beta-aminophosphonic acid derivative and preparation method thereof

The invention discloses a preparation method of a beta-aminophosphonic acid derivative. The preparation method comprises the following steps of dissolving N-(arylvinyl)benzamide, dialkyl phosphite, manganese acetate and potassium carbonate in a solvent, performing reaction at a room temperature to acquire a (2-benzamido-1-arylvinyl)dialkyl phosphonate derivative, and performing reductive hydrolyzation on a compound to acquire the beta-aminophosphonic acid derivative. By using an N-(arylvinyl)benzamide derivative as an initiator, the preparation method is available in raw material and various in preparation method. The preparation method is simple and short in synthetic route, mild in reaction condition, simple in reaction operation and aftertreatment process and better in yield and is suitable for scale production.

Beta-phosphono-enamine derivative and preparation method thereof

The invention discloses a preparation method for beta-phosphono-enamine derivative. The preparation method is characterized in comprising the following steps: dissolving enamine derivative, organic phosphine compound, manganese acetate and potassium carbonate in solvent, reacting at a room temperature, and obtaining the beta-phosphono-enamine derivative. According to the preparation method, the enamine derivative is taken as an initiator, raw materials are abundant, and categories are rich. The product obtained with the method disclosed by the invention has various types, can be directly usedand also can be used for further reacting with other ingredients. The method disclosed by the invention has the advantages of moderate reaction condition, high reaction speed, simple reaction operation and postprocessing process and good yield and is suitable for scale production.