Journal of Organic Chemistry p. 11932 - 11939 (2016)
Update date:2022-08-11
Topics:
Huang, Hai
Palmas, Jake
Kang, Jun Yong
Bifunctional N-heterocyclic phosphine (NHP)-thioureas have been successfully applied for phospha-Michael addition reaction of nitroalkenes to afford diversely substituted β-nitrodiazaphosphonates. This transformation takes place at room temperature under catalyst-free conditions and exhibits broad functional group tolerance. The key to success in catalyst, additive-free reaction conditions is the suitable hydrogen-bond activation of the nitro group by a Br?nsted acid (thiourea), which artfully combined with the highly nucleophilic NHP motif for a synergetic effect. Importantly, this transformation enables a two-step synthesis of pharmaceutically, biologically significant β-amino phosphonic acids.
View MoreGuangzhou Flower's Song Fine Chemical CO,. Ltd
Contact:+86-20-87475199
Address:No.12, Fenghuang 3 Road, Jiulong Industrial Park, Luogang District, Guangzhou. China
TIANJIN DONGRUXIANG MINERALS MARKETING CO.,LTD
Contact:22-58516360
Address:tianjin
Triumph International Development Limilted
website:http://www.jiashengchem.cn/
Contact:+86-536-7971999
Address:Yinhai Road,Shouguang
Contact:+86-20-32051076
Address:1105,Building A, International Business Incubator,Science City
Changzhou Litong Chemical Co., Ltd.
website:http://www.litonchem.com/
Contact:+86-519-86301238
Address:Laoba Rd, Hutang town Changzhou Jiangsu
Doi:10.1002/anie.200463006
(2005)Doi:10.1039/b605074c
(2006)Doi:10.1002/bkcs.11013
(2016)Doi:10.3390/molecules17010355
(2012)Doi:10.1016/j.tetlet.2008.10.027
(2008)Doi:10.1016/S0040-4039(01)01900-1
(2001)