28669-28-5

Upstream product

• 590-28-3 potassium cyanate 
• 3349-66-4 cyclobutanon-phenylhydrazone 
• 20730-03-4 butyric acid N'-phenyl-hydrazide 
• 917-61-3 sodium isocyanate 
• 100-63-0 phenylhydrazine 

Relevant academic research and scientific papers

Green preparation method of 1,2,4-triazol-3-one compound

The invention discloses a green preparation method of a 1,2,4-triazol-3-one compound. The green preparation method comprises the following steps: adding a nickel accelerant, triethylamine, chlorohydrazone and sodium cyanate into an organic solvent, conduc

Synthesis of 3 H-1,2,4-Triazol-3-ones via NiCl2-Promoted Cascade Annulation of Hydrazonoyl Chlorides and Sodium Cyanate

A nickel-promoted cascade annulation reaction for the facile synthesis of 3H-1,2,4-triazol-3-ones from readily available hydrazonoyl chlorides and sodium cyanate has been developed. The transformation occurs through a cascade nickel-promoted intermolecular nucleophilic addition-elimination process, intramolecular nucleophilic addition, and a hydrogen-transfer sequence. The method has been successfully applied for the construction of the core skeleton of the angiotensin II antagonist.

Rearrangement of 3,3-Disubstituted 1-Aryl-4,5-dihydro-5-oxo-3H-1,2,4-triazolium Tetrafluoroborates; Part 2. A Convenient Synthesis of 1,5-Annulated 1,2-Dihydro-2-phenyl-3H-1,2,4-triazol-3-ones

1-Isocyanato-1-(phenylazo)cycloalkanes 3 react with tetrafluoroboric acid to yield 3-spiro substituted 4,5-dihydro-5-oxo-1-phenyl-3H-1,2,4-triazolium tetrafluoroborates 4.Compounds 4 rearrange with ring expansion in good yield to give, after basic workup,