20730-03-4

Basic information

• Product Name: Butanoic acid, 2-phenylhydrazide
• Synonyms: N′-phenylbutanehydrazide;β-Butyryl-phenylhydrazin;butyric acid-(N'-phenyl-hydrazide);Buttersaeure-(N'-phenyl-hydrazid);Butyric acid N'-phenyl-hydrazide;N'-Butyryl-N-phenyl-hydrazin;N-Phenyl-N'-butyryl-hydrazin
• CAS NO: 20730-03-4
• Molecular Formula: C10H14N2O
• Molecular Weight: 178.234
• Mol File: 20730-03-4.mol

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-phenylhydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-phenylhydrazide(20730-03-4)
• EPA Substance Registry System: Butanoic acid, 2-phenylhydrazide(20730-03-4)

Safety Data

• Hazardous Substances Data: 20730-03-4(Hazardous Substances Data)

Upstream product

• 106-31-0 butanoic acid anhydride 
• 100-63-0 phenylhydrazine 
• 107-92-6 butyric acid 
• 141-75-3 butyryl chloride 
• 541-33-3 1,1-dichlorobutane 
• 7165-13-1 acetic butyric anhydride 

Downstream Products

• 93730-46-2 1-butyryl-2,4-diphenyl semicarbazide 
• 681466-22-8 5-oxo-1-phenyl-3-propyl-1,5-dihydro-[1,2,4]triazole-4-carboxylic acid amide 
• 15379-45-0 3-ethyloxindole 
• 99167-08-5 N-butyl-N'-phenylhydrazine 
• 19525-17-8 2-chloro-3-phenyl-5-propyl-2,3-dihydro-[1,3,4,2]oxadiazaphosphole 
• 1415212-81-5 C₁₂H₁₄N₂O₂ 
• 18655-74-8 2-chloro-3-phenyl-5-propyl-2,3-dihydro-[1,3,4,2]oxadiazaphosphole 2-sulfide 
• 541-35-5 butanamide 
• 62-53-3 aniline 

Relevant articles and documents

Synthesis of 3 H-1,2,4-Triazol-3-ones via NiCl2-Promoted Cascade Annulation of Hydrazonoyl Chlorides and Sodium Cyanate

A nickel-promoted cascade annulation reaction for the facile synthesis of 3H-1,2,4-triazol-3-ones from readily available hydrazonoyl chlorides and sodium cyanate has been developed. The transformation occurs through a cascade nickel-promoted intermolecular nucleophilic addition-elimination process, intramolecular nucleophilic addition, and a hydrogen-transfer sequence. The method has been successfully applied for the construction of the core skeleton of the angiotensin II antagonist.

A formal [3+2] cycloaddition reaction of: N -methylimidazole as a masked hydrogen cyanide: Access to 1,3-disubstitued-1 H -1,2,4-triazoles

N-Methylimidazole (NMI) can act as a masked HCN in the synthesis of 1,3-disubstitued-1H-1,2,4-triazoles via a formal cycloaddition reaction of hydrazonoyl chloride with NMI. The product was proved to be formed via an initial nucleophilic substitution of hydrazonoyl chloride with NMI following cyclization and two sequential C-N bond cleavages. This journal is

Synthesis of Spirobidihydropyrazole through Double 1,3-Dipolar Cycloaddition of Nitrilimines with Allenoates

The double 1,3-dipolar cycloaddition of allenoates with nitrilimines has been achieved under mild reaction conditions, affording a variety of spirobidihydropyrazoles in moderate to excellent yields with excellent diastereoselectivities. The reaction diastereoselectively constructs double dihydropyrazole moieties and two chiral centers including a spiro carbon center.

Preparation, properties, and reductive alkylation of arylhydrazides

1 [-Acy]-2-arylhydrazines (1), readily obtained in high yield from the condensation of arylhydrazines and the appropriate liquid carboxylic acid (2), underwent reductive alkylation with the same or different liquid carboxylic acids (2) and NaBH4 to give 1-acyl-2-alkyl-2-arylhydrazines (3) in good to moderate yields. The carboxylic acid has both the role of supplying the entering alkyl group and of acting as solvent. Most likely, it also modifies the BH4- anion to an active reducing agent under those conditions. The 1H NMR criteria for identifying the location of acylation of hydrazines and E and Z isomers are given. The MS spectra of the prepared hydrazides were analyzed in order to identify relevant structural features leading to specific fragmentations.